Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 314 Jay St., La Crosse | Chicago (Bus Station) | CheapestFastest | ||||
| Bus | La Crosse (U of WI) | Chicago (Bus Station) | No tags |
Last refresh of the prices: Yesterday at 8:38 PM CST.
Compare 2 ways to travel from La Crosse to Chicago
Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes and with fares starting at just R 574, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 759 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the seats but often complained with the Wi-Fi. Jefferson Lines ticket prices on this trip start at R 3 163
Frequently asked questions about travelling from La Crosse, WI to Chicago by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from La Crosse to Chicago?
The cheapest bus tickets from La Crosse to Chicago start at R 3 163. The average price for this route is around R 3 163. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from La Crosse to Chicago?
The average bus journey time from La Crosse to Chicago is 17h 15m, covering a distance of 364 km. The fastest bus gets you there in 16h 55m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Chicago route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from La Crosse to Chicago?
The earliest bus departs from La Crosse to Chicago at 12:25. And the latest bus departs at 12:50.
What are the CO₂ emissions for the bus trip from La Crosse to Chicago?
A bus trip from La Crosse to Chicago produces an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Chicago was searched and found on 18 Dec 2025 with a price of R 3 392To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago as early as possible.
You can expect to pay from R 3 392 to R 3 392 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at R 3 392, which is on 2025-12-18.
