Find coaches from La Crosse, WI to Chicago

Next departures

Next departures from La Crosse to Chicago on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson Lines
La Crosse MTU Transit Center
Chicago (Bus Station)CheapestFastest
Jefferson Lines
632 17th Street North
Chicago (Bus Station)No tags

Last refresh of the prices: Yesterday at 11:49 PM CDT.

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Compare 2 ways to travel from La Crosse to Chicago

busbud logoWe recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes and with fares starting at just US$34, it presents an excellent value for a comfortable ride.

3train per day
5h 8mAverage duration
366 kmDistance
33kgCO₂ emissions
Bus
Average priceUS$184 - US$203Average duration17h 15m
9kg CO₂e
Train
Average priceUS$34 - US$266Average duration5h 8m
33kg CO₂e

Bus La Crosse, WI to Chicago: Trip Overview

Average ticket priceUS$184
Average bus trip duration17h 15m
Number of daily buses2
Earliest bus departure12:25
Distance365 km
Latest bus departure12:50

La Crosse to Chicago Bus

Busbud helps you find a bus from La Crosse to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from La Crosse to Chicago from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from La Crosse, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip La Crosse, WI - Chicago

  1. How much does a bus ticket from La Crosse to Chicago cost?

    The bus ticket price from La Crosse to Chicago starts at US$184. The best way to find cheap bus tickets from La Crosse to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from La Crosse to Chicago?

    The average travel time between La Crosse and Chicago is around 17h 15m, although the fastest bus will take about 17h 15m. This is the time it takes to travel the 367 km that separates the two cities.

  3. How many daily bus connections are there between La Crosse and Chicago?

    The number of buses from La Crosse to Chicago can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from La Crosse to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from La Crosse to Chicago?

    When taking the bus from La Crosse to Chicago, you can travel comfortably and safely with Jefferson Lines.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/10
No data
30/10
US$179
Today
US$179
01/11
No data
02/11
No data
03/11
No data
04/11
No data
05/11
No data
busbud logoThe cheapest trip from La Crosse, WI to Chicago was searched and found on 30 Oct 2025 with a price of US$179

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between La Crosse and Chicago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from La Crosse to Chicago, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Crosse to Chicago.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from La Crosse to Chicago.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

You can also go to Chicago by train

Train from La Crosse, WI to Chicago

Why choose Busbud?

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