Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | La Crosse MTU Transit Center | Chicago (Bus Station) | CheapestFastest | ||||
| Bus | 632 17th Street North | Chicago (Bus Station) | No tags |
Last refresh of the prices: Today at 21:45 CST.
Compare 2 ways to travel from La Crosse to Chicago
Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes and with fares starting at just £27, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 759 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the seats but often complained with the Wi-Fi. Jefferson Lines ticket prices on this trip start at £144
Frequently asked questions about travelling by bus from La Crosse, WI to Chicago
What's the distance between La Crosse and Chicago by coach?
The journey from La Crosse to Chicago by coach covers an approximate distance of 227 miles (367 km).
How can I get from La Crosse to Chicago without driving?
You can reach Chicago from La Crosse by coach, as there are regular services between the two locations. Depending on your preferences, another alternative is to explore ridesharing trips.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Chicago was searched and found on 25 Nov 2025 with a price of £141To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago as early as possible.
You can expect to pay from £141 to £155 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £141, which is on 2025-11-25.
