Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | La Crosse MTU Transit Center | Chicago (Bus Station) | CheapestFastest | ||||
| Bus | 632 17th Street North | Chicago (Bus Station) | No tags |
Last refresh of the prices: Today at 3:10 PM CST.
Compare 2 ways to go from La Crosse to Chicago
Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes, and with fares starting at just $49, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 759 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the seats but often complained with the WiFi. Jefferson Lines ticket prices on this trip start at $266
Frequently asked questions about travelling from La Crosse, WI to Chicago by bus
How far is La Crosse from Chicago?
The distance between La Crosse and Chicago is approximately 367 km (227 miles).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Chicago was searched and found on Nov 25, 2025 with a price of $259To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago, as early as possible.
You can expect to pay from $259 to $285 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $259 which is on 2025-11-25.
