Bus Tickets from La Serena to Santiago

Find affordable bus tickets from La Serena to Santiago with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayMay 19
from US$10
TomorrowMay 20
from US$9
WedMay 21
from US$16
ThuMay 22
from US$9
FriMay 23
from US$9
SatMay 24
from US$13
SunMay 25
from US$10
MonMay 26

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 20 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 20 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Buses RomaniBuses Romani
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 20 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 20 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: May 20 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 20 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: May 20 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 20 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: May 20 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 21 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: ParaviasParavias
    Vehicle: BusDuration:

Last refresh of the prices: Today at 9:04 AM -04.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus La Serena to Santiago: Trip Overview

Average Ticket PriceUS$16
Average Bus Trip Duration6h 15m
Number of daily buses67
Earliest bus departure12:05am
Distance388 km
Latest bus departure11:59pm

La Serena to Santiago Bus

With Busbud, comparing and booking tickets for a bus from La Serena to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from La Serena to Santiago will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from La Serena to Santiago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip La Serena - Santiago

  1. How long is the trip from La Serena to Santiago by bus?

    The trip from La Serena to Santiago will take on average 6h 15m. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 5h 10m.

  2. What is the travel distance from La Serena to Santiago?

    The distance between La Serena and Santiago is around 398 km (247 miles).

  3. What are the departure and arrival locations for buses traveling from La Serena to Santiago?

    Buses traveling this route start their trip at Terminal de Buses La Serena, in La Serena, and end it at San Borja, in Santiago.

  4. What is the cheapest way to travel from La Serena to Santiago?

    If you're on a budget, consider traveling by bus to Santiago from La Serena; it tends to be more affordable. Starting at US$9, this bus is the most cost-effective option for your journey.

  5. How much does the bus ticket cost from La Serena to Santiago?

    Taking the bus from La Serena to Santiago costs on average US$16.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-17
US$12
05-18
US$16
Today
US$9
05-20
US$9
05-21
US$15
05-22
US$8
05-23
US$9
05-24
US$12
busbud logoThe cheapest trip from La Serena to Santiago was searched and found on May 22, 2025 with a price of US$8

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena to Santiago, as early as possible.

You can expect to pay from US$8 to US$27 for a bus ticket from La Serena to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$8 which is on 2025-05-22.

Usually Pullman San Andrés, PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from La Serena to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from La Serena to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from La Serena to Santiago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from La Serena to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to La Serena by bus?

Bus from La Serena to Santiago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting La Serena

Buses Leaving from La Serena

Buses Going to La Serena

Popular Buses Connecting Santiago

Buses Leaving from Santiago

Buses Going to Santiago