Bus Tickets from La Serena, CL to Santiago, CL

Next departures

Next departures for La Serena to Santiago on October 7
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Cikbus Elité
Terminal de Buses La Serena
Terminal de Buses San Borja - San Francisco de BorjaCheapest
Pullman San Andrés
Terminal de Buses La Serena
San BorjaFastest
Cikbus Elité
Terminal de Buses La Serena
Terminal de Buses San Borja - San Francisco de BorjaNo tags
Pluss Chile
Terminal de Buses La Serena
San BorjaNo tags
Paravias
Terminal de Buses La Serena
San BorjaNo tags

Last refresh of the prices: Today at 4:53 PM -03.

Accepted payments

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Bus La Serena, CL to Santiago, CL: Trip Overview

Average Ticket PriceUS$18
Average Bus Trip Duration6h 10m
Number of daily buses76
Earliest bus departure12:05am
Distance398 km
Latest bus departure11:59pm

La Serena to Santiago Bus

With Busbud, comparing and booking tickets for a bus from La Serena to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from La Serena to Santiago will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from La Serena to Santiago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip La Serena, CL - Santiago, CL

  1. What is the travel distance from La Serena to Santiago?

    The distance between La Serena and Santiago is around 398 km (247 miles).

  2. What are the departure and arrival locations for buses traveling from La Serena to Santiago?

    Buses traveling this route start their trip at Terminal de Buses La Serena, in La Serena, and end it at San Borja, in Santiago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-04
US$13
10-05
US$14
Today
US$13
10-07
US$9
10-08
US$9
10-09
US$9
10-10
US$9
10-11
US$9
busbud logoThe cheapest trip from La Serena, CL to Santiago, CL was searched and found on Oct 7, 2025 with a price of US$9

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Santiago, CL, as early as possible.

You can expect to pay from US$9 to US$40 for a bus ticket from La Serena, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$9 which is on 2025-10-07.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from La Serena to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from La Serena to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from La Serena to Santiago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from La Serena to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to La Serena, CL by bus?

Bus from Santiago, CL to La Serena, CL

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