How can I travel from La Serena to Santiago without a car?

Taking the bus is the best way to travel to Santiago without a car. The bus provides a cost-effective, safe, and easy way to travel between the two cities. Taking a ride with other travelers through carpool services is an additional option to consider.

How long does it take to get to Santiago from La Serena by bus?

On average, the trip from La Serena to Santiago takes around 6h 15m, but the fastest bus can get you there in about 5h 10m. This is the time it takes to travel the 247 miles (398 km) that separate the two cities.

What is the travel distance from La Serena to Santiago?

The distance separating La Serena and Santiago is 247 miles (398 km).

What are the departure and arrival stations when taking the bus from La Serena to Santiago?

The majority of buses traveling from La Serena to Santiago start their journey at Terminal de Buses La Serena and wind up at San Borja. These are the most popular departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

What is the most cost-effective way to travel from La Serena to Santiago?

You can save a lot of money on your trip from La Serena to Santiago by choosing to travel by bus. The lowest tickets for this trip cost as little as $9.

How much are the bus tickets from La Serena to Santiago?

You can expect to pay around $16 for a bus ticket. In the past 30 days, prices have fluctuated between $9 and $80, so it's best to compare them to make sure you get the best deal.

What are the best sights and things to do in Santiago?

Once in Santiago, you can start exploring the city and discover its surroundings. The top sights and things to do are Parque O'Higgins, Plaza de Armas, Museo de la Memoria y los Derechos Humanos, El Biógrafo and Cerro San Cristóbal.

La Serena, CL to Santiago, CL Bus Tickets

TodayMay 8

from $9

TomorrowMay 9

from $9

SatMay 10

from $9

SunMay 11

from $9

MonMay 12

from $11

TueMay 13

from $8

WedMay 14

from $8

ThuMay 15

from $8

Cheap buses leaving tomorrow

One passenger / one way

This trip is recommended because it is: Cheapest
Departure time: May 9 at 9:00am
Departure city: La Serena
Departure location: Terminal de Buses La Serena
Arrival time: May 9 at 3:00pm
Destination city: Santiago
Destination location: Terminal de Buses San Borja - San Francisco de Borja
Operated by: Buses Romani
Vehicle: BusDuration: 6h
This trip is recommended because it is: Fastest
Departure time: May 9 at 5:05am
Departure city: La Serena
Departure location: Terminal de Buses La Serena
Arrival time: May 9 at 10:35am
Destination city: Santiago
Destination location: San Borja
Operated by: Pullman San Andrés
Vehicle: BusDuration: 5h 30m
Departure time: May 9 at 9:30am
Departure city: La Serena
Departure location: Terminal de Buses La Serena
Arrival time: May 9 at 4:30pm
Destination city: Santiago
Destination location: Terminal de Buses San Borja - San Francisco de Borja
Operated by: Cikbus Elité
Vehicle: BusDuration: 7h
Departure time: May 9 at 1:30am
Departure city: La Serena
Departure location: Terminal de Buses La Serena
Arrival time: May 9 at 8:00am
Destination city: Santiago
Destination location: San Borja
Operated by: Pluss Chile
Vehicle: BusDuration: 6h 30m
Departure time: May 9 at 1:15am
Departure city: La Serena
Departure location: Terminal de Buses La Serena
Arrival time: May 9 at 7:55am
Destination city: Santiago
Destination location: San Borja
Operated by: Paravias
Vehicle: BusDuration: 6h 40m

Accepted payments

Bus La Serena to Santiago: Trip Overview

Average ticket price$16

Average bus trip duration6h 15m

Number of daily buses66

Earliest bus departure12:00am

Distance247 miles (398 km)

Latest bus departure11:59pm

Compare bus companies

Pluss Chile

4/568 reviews

Staff4.5

Timeliness3.9

Cleanliness4.7

Wifi1.5

Cikbus Elité

4/5111 reviews

Staff4.6

Timeliness3.1

Cleanliness4.1

Wifi1.8

FlixBus

3.5/58,539 reviews

Staff4.1

Timeliness4

Cleanliness4.1

Wifi2.6

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Buses Andimar

4.5/544 reviews

Staff4.4

Timeliness4.5

Cleanliness4.4

Wifi1

Buses Romani

4/541 reviews

Staff4.7

Timeliness4.7

Cleanliness4.7

Wifi0.7

Pullman San Andres

3.5/513 reviews

Timeliness0

Condor Bus

3.5/519 reviews

Buses Paravias

3/568 reviews

Staff3.3

Timeliness3.7

Cleanliness3

Wifi1.8

Based on 68 reviews, the company was rated 3 stars on Busbud. Travelers were especially satisfied with the timeliness and the departure location but often complained with the wifi. Buses Paravias ticket prices on this trip start at $12.00

Paravias La Serena Santiago recent customer reviews

I had selected an upstairs aisle seat and ended up in a cramped downstairs window seat. Uncomfortable and no place to put personal belongings.

Stewart L.

January 10, 2018

Serena Mar

4/512 reviews

Clikbus

4.5/53 reviews

Staff5

Timeliness5

Cleanliness3.4

Wifi0

CL bus companies: FlixBus, Via Tac, Andesmar, Cruz del Sur, buses TranSantin, CATA Internacional, Pluss Chile

La Serena to Santiago Bus

With Busbud, comparing and booking tickets for a bus from La Serena to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from La Serena to Santiago will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from La Serena to Santiago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Where are the popular stops in La Serena and Santiago?

Stops in La Serena

A - Terminal de Buses La Serena

B - Rotonda La Serena

Stops in Santiago

A - San Borja

B - Santiago

C - Pajaritos

D - Terminal Sur

E - Terminal Los Héroes

F - Terminal ETM

Frequently asked questions for your trip La Serena - Santiago

How can I travel from La Serena to Santiago without a car?
How long does it take to get to Santiago from La Serena by bus?
What is the travel distance from La Serena to Santiago?
What are the departure and arrival stations when taking the bus from La Serena to Santiago?
What is the most cost-effective way to travel from La Serena to Santiago?
How much are the bus tickets from La Serena to Santiago?
What are the best sights and things to do in Santiago?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

05/06

$13

05/07

$11

Today

$9

05/09

$9

05/10

$9

05/11

$9

05/12

$11

05/13

$8

The cheapest trip from La Serena to Santiago was searched and found on May 13, 2025 with a price of $8

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena to Santiago, as early as possible.

You can expect to pay from $8 to $25 for a bus ticket from La Serena to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at $8 which is on 2025-05-13.

Usually Cikbus Elité, Buses Romani, Serena Mar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from La Serena to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from La Serena to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from La Serena to Santiago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from La Serena to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to La Serena by bus?

Bus from La Serena to Santiago

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

One passenger / one way

Cheap buses leaving tomorrow

One passenger / one way

One passenger / one way

One passenger / one way

One passenger / one way

One passenger / one way

One passenger / one way

One passenger / one way

Bus La Serena to Santiago: Trip Overview

Compare bus companies

La Serena to Santiago Bus

Where are the popular stops in La Serena and Santiago?

Frequently asked questions for your trip La Serena - Santiago

How can I travel from La Serena to Santiago without a car?

How long does it take to get to Santiago from La Serena by bus?

What is the travel distance from La Serena to Santiago?

What are the departure and arrival stations when taking the bus from La Serena to Santiago?

What is the most cost-effective way to travel from La Serena to Santiago?

How much are the bus tickets from La Serena to Santiago?

What are the best sights and things to do in Santiago?

Find cheapest prices for buses

About Bus Travel

Bus Travel Tips

Did you know?

Will you be returning to La Serena by bus?

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

People from around the world trust Busbud

Popular Buses Connecting La Serena

Buses Leaving from La Serena

Buses Going to La Serena

Popular Buses Connecting Santiago

Buses Leaving from Santiago

Buses Going to Santiago

Popular routes in this country

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