Bus from La Serena, CL to Santiago, CL: Tickets & Schedules

Next bus departures

Next departures for La Serena to Santiago on February 12
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Buses RomaniBus
Terminal de Buses La Serena
Terminal de Buses San Borja - San Francisco de BorjaCheapest
AndimarBus
La Serena (Bus terminal La Serena)
Terminal San BorjaFastest
Cikbus ElitéBus
Terminal de Buses La Serena
Terminal de Buses San Borja - San Francisco de BorjaNo tags
Pluss ChileBus
Terminal de Buses La Serena
San BorjaNo tags
ParaviasBus
Terminal de Buses La Serena
San BorjaNo tags

Last refresh of the prices: Today at 12:00 AM -03.

Get from La Serena to Santiago

This route is served by bus only

The journey takes about 6 hours 30 minutes and with fares starting at just $11, it presents an excellent value for a comfortable ride.

91bus per day
6h 30mAverage Duration
247 milesDistance
10kgCO₂ emissions

Frequently asked questions about traveling from La Serena, CL to Santiago, CL by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from La Serena to Santiago?

    The cheapest bus tickets from La Serena to Santiago start from $11. The average price for this route is around $25. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from La Serena to Santiago?

    The average bus trip duration from La Serena to Santiago is 6h 30m, covering a distance of 247 miles (399 km). The quickest bus can get you there in 5h 40m and is operated by FlixBus.

  3. Which bus companies service the La Serena to Santiago route?

    Several major bus companies operate on this route with 91 buses available per day, including services from Pluss Chile, FlixBus, Cikbus Elité, Buses Andimar, Pullman San Andres, Buses Romani, Buses Paravias, Serena Mar, Turisnorte, Condor Bus.

  4. What is the earliest and latest departure time for the bus from La Serena to Santiago?

    The earliest bus departs from La Serena to Santiago at 12:05am. And the latest bus departs at 11:59pm.

  5. What are the CO₂ emissions for the bus trip from La Serena to Santiago?

    A bus trip from La Serena to Santiago generates an estimated 10 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

  6. What is the best bus company from La Serena to Santiago?

    According to Busbud customers, the highest-rated bus company on this route is Buses Andimar, with an average rating of 4.0 out of 5 stars based on 60 reviews.

  7. Which bus company has the best Wi-Fi from La Serena to Santiago?

    Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

  8. Which bus company has the most timely service from La Serena to Santiago?

    According to Busbud traveler reviews, the most timely bus company on this route is Buses Romani, with a punctuality rating of 4.5 out of 5 stars.

  9. Which bus company has the cleanest buses from La Serena to Santiago?

    According to Busbud traveler reviews, the bus company with the cleanest buses on this route is Pluss Chile, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
02/09
$23
02/10
$20
Today
$18
02/12
$18
02/13
$18
02/14
$18
02/15
$18
02/16
$18
busbud logoThe cheapest trip from La Serena, CL to Santiago, CL was searched and found on Feb 16, 2026 with a price of $18

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Santiago, CL, as early as possible.

You can expect to pay from $18 to $50 for a bus ticket from La Serena, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $18 which is on 2026-02-16.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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