Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mainz | Brussels North Train Station | CheapestFastest | ||||
| Bus | Mainz | Brussels North Train Station | No tags | ||||
| Bus | Mainz | Brussels Airport BRU (Parking P14) | No tags |
Last refresh of the prices: Today at 7:13 AM CEST.
Compare 2 ways to travel from Mainz to Brussels
Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 5 hours 45 minutes and with fares starting at just ₪95, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mainz and Brussels?
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz
Stops in Brussels
- A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium - B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium - C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium - D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Compare bus companies
Based on 12812 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. FlixBus ticket prices on this trip start at ₪95
Frequently asked questions about travelling from Mainz to Brussels by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Mainz to Brussels?
The cheapest bus tickets from Mainz to Brussels start at ₪95. The average price for this route is around ₪134. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Mainz to Brussels?
The average bus journey time from Mainz to Brussels is 5h 45m, covering a distance of 292 km. The fastest bus gets you there in 5h 45m and is operated by FlixBus.
Which bus companies service the Mainz to Brussels route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Mainz to Brussels?
The earliest bus departs from Mainz to Brussels at 08:20. And the latest bus departs at 22:40.
What are the CO₂ emissions for the bus trip from Mainz to Brussels?
A bus trip from Mainz to Brussels produces an estimated 7.28445 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Brussels was searched and found on 10 Jun 2026 with a price of ₪84To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mainz to Brussels as early as possible.
You can expect to pay from ₪84 to ₪267 for a bus ticket from Mainz to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at ₪98, which is on 2026-06-13.
