Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mainz | Brussels North Train Station | CheapestFastest | ||||
| Bus | Mainz | Brussels North Train Station | No tags | ||||
| Bus | Mainz | Brussels Airport | No tags |
Last refresh of the prices: Today at 15:24 CET.
Compare 3 ways to travel from Mainz to Brussels
Among the sustainable travel choices, the carpool stands out as a good way to reach Brussels. The journey takes about 4 hours and with fares starting at just £28, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mainz and Brussels?
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz - Cflibco.com bus stop, Kaiser-Wilhelm-Ring, 55118 Mainz, Germany
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Compare bus companies
Based on 11459 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £22
Frequently asked questions about travelling by bus from Mainz to Brussels
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Mainz to Brussels?
The cheapest coach tickets from Mainz to Brussels start from £22. The average price for this route is around £33. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Mainz to Brussels?
The average bus journey time from Mainz to Brussels is 7h 30m, covering a distance of 182 miles. The fastest bus can take you there in 5h 45m and is operated by FlixBus.
Which bus companies service the Mainz to Brussels route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Mainz to Brussels?
The earliest bus departs from Mainz to Brussels at 01:00. And the latest bus departs at 22:40.
What are the CO₂ emissions for the bus trip from Mainz to Brussels?
A bus journey from Mainz to Brussels produces an estimated 7 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Brussels was searched and found on 2 Dec 2025 with a price of £21To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mainz to Brussels as early as possible.
You can expect to pay from £21 to £42 for a bus ticket from Mainz to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at £21, which is on 2025-12-02.
