Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | St. Paul & N5th | La Crosse (U of WI) | CheapestFastest | ||||
| Bus | St. Paul & N5th | 314 Jay St., La Crosse | No tags |
Last refresh of the prices: Yesterday at 12:51 PM CST.
Compare 2 ways to travel from Milwaukee to La Crosse
Among the sustainable travel choices, the Bus stands out as a good way to reach La Crosse. The journey takes about 4 hours 15 minutes and with fares starting at just R 665, it presents an excellent value for a comfortable ride.
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Frequently asked questions about travelling from Milwaukee to La Crosse, WI by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Milwaukee to La Crosse?
The cheapest bus tickets from Milwaukee to La Crosse start at R 665. The average price for this route is around R 732. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Milwaukee to La Crosse?
The average bus journey time from Milwaukee to La Crosse is 4h 15m, covering a distance of 282 km. The fastest bus gets you there in 3h 25m and is operated by Jefferson Lines.
Which bus companies service the Milwaukee to La Crosse route?
Several major bus companies operate on this route with 2 buses available per day, including services from Jefferson Lines, Megabus.
What is the earliest and latest departure time for the bus from Milwaukee to La Crosse?
The earliest bus departs from Milwaukee to La Crosse at 08:50. And the latest bus departs at 10:15.
What are the CO₂ emissions for the bus trip from Milwaukee to La Crosse?
A bus trip from Milwaukee to La Crosse produces an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Milwaukee to La Crosse?
According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 766 reviews.
Which bus company has the best Wi-Fi from Milwaukee to La Crosse?
Based on reviews on Busbud, the bus company Megabus has the best Wi-Fi rating with a score of 2.4.
Which bus company offers the most punctual service from Milwaukee to La Crosse?
According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines, with a punctuality rating of 3.7 out of 5 stars.
Which bus company has the cleanest buses from Milwaukee to La Crosse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Jefferson Lines, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milwaukee to La Crosse, WI was searched and found on 21 Jan 2026 with a price of R 645To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to La Crosse, WI as early as possible.
You can expect to pay from R 645 to R 645 for a bus ticket from Milwaukee to La Crosse, WI based on the last 2 days. You can expect to find the cheapest price for the trip at R 645, which is on 2026-01-24.
What's the cheapest way to go from Milwaukee to La Crosse, WI?
The Bus is the cheapest travel choice for this destination
