Bus from Milwaukee to La Crosse, WI: Tickets & Timetables

Next bus departures

Next departures from Milwaukee to La Crosse on 9 December
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson LinesBus
    		St. Paul & N5th
    		La Crosse (U of WI)CheapestFastest
    Megabus USBus
      		Milwaukee Bus Station, St. Paul & N6th road.
      		La Crosse WI - University of Wisconsin (LSW)No tags
      Jefferson LinesBus
        		St. Paul & N5th
        		314 Jay St., La CrosseNo tags
        Megabus USBus
          		Milwaukee Bus Station, St. Paul & N6th road.
          		La Crosse St Andrew StNo tags

          Last refresh of the prices: Today at 1:27 AM CST.

          Compare 2 ways to travel from Milwaukee to La Crosse

          We recommend taking the bus

          Among the sustainable travel choices, the bus stands out as a good way to reach La Crosse. The journey takes about 4 hours 45 minutes and with fares starting at just R 700, it presents an excellent value for a comfortable ride.

          2bus per day
          4h 45mAverage duration
          284 kmDistance
          7kgCO₂ emissions
          Bus
          		Average priceR 700 - R 978Average duration4h 45m
          7kg CO₂e
          Train
          		Average priceR 454 - R 2 219Average duration3h 44m
          26kg CO₂e

          Frequently asked questions about travelling from Milwaukee to La Crosse, WI by bus

          Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

          1. How much is the bus ticket from Milwaukee to La Crosse?

            The cheapest bus tickets from Milwaukee to La Crosse start at R 700. The average price for this route is around R 787. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

          2. How long is the bus journey from Milwaukee to La Crosse?

            The average bus journey time from Milwaukee to La Crosse is 4h 45m, covering a distance of 284 km. The fastest bus gets you there in 3h 25m and is operated by Jefferson Lines.

          3. Which bus companies service the Milwaukee to La Crosse route?

            Several major bus companies operate on this route with 2 buses available per day, including services from Megabus, Jefferson Lines.

          4. What is the earliest and latest departure time for the bus from Milwaukee to La Crosse?

            The earliest bus departs from Milwaukee to La Crosse at 09:00. And the latest bus departs at 10:15.

          5. What are the CO₂ emissions for the bus trip from Milwaukee to La Crosse?

            A bus trip from Milwaukee to La Crosse produces an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

          6. What is the best bus company from Milwaukee to La Crosse?

            According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 759 reviews.

          7. Which bus company has the best Wi-Fi from Milwaukee to La Crosse?

            Based on reviews on Busbud, the bus company Jefferson Lines has the best Wi-Fi rating with a score of 3.1.

          8. Which bus company offers the most punctual service from Milwaukee to La Crosse?

            According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines, with a punctuality rating of 3.8 out of 5 stars.

          9. Which bus company has the cleanest buses from Milwaukee to La Crosse?

            According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Megabus, with a cleanliness rating of 4.3 out of 5 stars.

          Find cheapest prices for buses

          Price is for a one-way ticket for one passenger and based on past searches.

          Best price found
          06/12
          R 749
          07/12
          R 749
          Today
          R 749
          09/12
          R 749
          10/12
          R 749
          11/12
          R 749
          12/12
          R 749
          13/12
          R 749
          busbud logoThe cheapest trip from Milwaukee to La Crosse, WI was searched and found on 06 Dec 2025 with a price of R 749

          To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to La Crosse, WI as early as possible.

          You can expect to pay from R 749 to R 940 for a bus ticket from Milwaukee to La Crosse, WI based on the last 2 days. You can expect to find the cheapest price for the trip at R 749, which is on 2025-12-09.

          What's the cheapest way to go from Milwaukee to La Crosse, WI?

          busbud logoThe bus is the cheapest travel choice for this destination

          People from around the world trust Busbud

          ‌