Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | St. Paul & N5th | 632 17th Street North | CheapestFastest | ||||
 | Bus | Milwaukee Bus Station, St. Paul & N6th road. | La Crosse WI - University of Wisconsin (LSW) | No tags | ||||
| Bus | St. Paul & N5th | La Crosse MTU Transit Center | No tags | ||||
| Bus | Milwaukee Bus Station, St. Paul & N6th road. | La Crosse St Andrew St | No tags |
Last refresh of the prices: Yesterday at 10:53 AM CST.
Compare 2 ways to go from Milwaukee to La Crosse
Among the sustainable travel choices, the bus stands out as the good way to reach La Crosse. The journey takes about 4 hours 45 minutes and with fares starting at just $41, it presents an excellent value for a comfortable ride.
Compare bus companies
Frequently asked questions about traveling from Milwaukee to La Crosse, WI by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Milwaukee to La Crosse?
The cheapest bus tickets from Milwaukee to La Crosse start from $41. The average price for this route is around $46. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Milwaukee to La Crosse?
The average bus trip duration from Milwaukee to La Crosse is 4h 45m, covering a distance of 176 miles (284 km). The quickest bus can get you there in 3h 25m and is operated by Jefferson Lines.
Which bus companies service the Milwaukee to La Crosse route?
Several major bus companies operate on this route with 2 buses available per day, including services from Megabus, Jefferson Lines.
What is the earliest and latest departure time for the bus from Milwaukee to La Crosse?
The earliest bus departs from Milwaukee to La Crosse at 9:00am. And the latest bus departs at 10:15am.
What are the CO₂ emissions for the bus trip from Milwaukee to La Crosse?
A bus trip from Milwaukee to La Crosse generates an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Milwaukee to La Crosse?
According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 759 reviews.
Which bus company has the best Wi-Fi from Milwaukee to La Crosse?
Based on reviews on Busbud, the bus company Jefferson Lines has the best Wi-Fi rating with a score of 3.1.
Which bus company has the most timely service from Milwaukee to La Crosse?
According to Busbud traveller reviews, the most timely bus company on this route is Jefferson Lines, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from Milwaukee to La Crosse?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Megabus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milwaukee to La Crosse, WI was searched and found on Nov 27, 2025 with a price of $43To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to La Crosse, WI, as early as possible.
You can expect to pay from $43 to $54 for a bus ticket from Milwaukee to La Crosse, WI based on the last 2 days. You can expect to find the cheapest price for the trip at $43 which is on 2025-11-30.
What's the cheapest way to go from Milwaukee to La Crosse, WI?
The bus is the cheapest travel choice for this destination
