Find coaches from San Ysidro, CA to Santa Ana, US

Next departures

Next departures from San Ysidro to Santa Ana on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
San Ysidro Bus terminal
Santa Ana Bus StationCheapest
Los Limousines
San Ysidro Greyhound Bus Station
Santa Ana E Santa Ana BlvdFastest
FlixBus
San Ysidro Bus terminal
Anaheim Regional Transportation Intermodal CenterNo tags
Greyhound Lines, Inc.
San Ysidro Bus terminal
Anaheim Regional Transportation Intermodal CenterNo tags
Los Limousines
San Ysidro Greyhound Bus Station
Santa Ana E Santa Ana BlvdNo tags

Last refresh of the prices: Yesterday at 3:59 PM PDT.

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Get from San Ysidro to Santa Ana

busbud logoThis route is served by bus only

The journey takes about 2 hours 45 minutes, and with fares starting at just US$24, it presents an excellent value for a comfortable ride.

19bus per day
2h 45mAverage duration
155 kmDistance
4kgCO₂ emissions

Bus San Ysidro, CA to Santa Ana, US: Trip Overview

Average ticket priceUS$45
Average bus trip duration2h 45m
Number of daily buses19
Earliest bus departure01:15
Distance155 km
Latest bus departure22:00

San Ysidro to Santa Ana Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Ysidro to Santa Ana.

Bus service from San Ysidro to Santa Ana will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from San Ysidro, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip San Ysidro, CA - Santa Ana, US

  1. How much does a bus ticket from San Ysidro to Santa Ana cost?

    The bus ticket price from San Ysidro to Santa Ana starts at US$24. The best way to find cheap bus tickets from San Ysidro to Santa Ana is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from San Ysidro to Santa Ana?

    The average travel time between San Ysidro and Santa Ana is around 2h 45m, although the fastest bus will take about 2h. This is the time it takes to travel the 154 km that separates the two cities.

  3. How many daily bus connections are there between San Ysidro and Santa Ana?

    The number of buses from San Ysidro to Santa Ana can differ depending on the day of the week. On average, there are 19 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Ysidro to Santa Ana by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from San Ysidro to Santa Ana?

    When taking the bus from San Ysidro to Santa Ana, you can travel comfortably and safely with Los Limousines, FlixBus, Greyhound.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/10
US$21
30/10
US$22
Today
US$23
01/11
US$21
02/11
US$18
03/11
US$20
04/11
US$17
05/11
US$18
busbud logoThe cheapest trip from San Ysidro, CA to Santa Ana, US was searched and found on 04 Nov 2025 with a price of US$17

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Santa Ana, US as early as possible.

You can expect to pay from US$17 to US$59 for a bus ticket from San Ysidro, CA to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$17, which is on 2025-11-04.

Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Ysidro to Santa Ana but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from San Ysidro to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Ysidro to Santa Ana.

Tune out to the fine sounds of your best music playlist on your bus trip from San Ysidro to Santa Ana while indulging in miles on end of beautiful scenic views.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to San Ysidro, CA by bus?

Bus from Santa Ana, US to San Ysidro, CA

Why choose Busbud?

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