What is the distance between San Ysidro and Santa Ana?

The distance between the two cities is 96 miles (154 km).

What are the departure and arrival stations when taking the bus from San Ysidro to Santa Ana?

If you're headed to Santa Ana from San Ysidro, chances are that your bus will depart from San Ysidro Greyhound Bus Station and arrive at Santa Ana Greyhound Bus Station. These are the most popular departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

Bus San Ysidro to Santa Ana from $17 | Refundable Tickets

Next departures

Next departures for San Ysidro to Santa Ana on November 13
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
6:00am	San Ysidro Bus terminal	2h 40m	8:40am	Santa Ana Bus Station	Cheapest
3:45pm	San Ysidro Bus terminal	2h 10m	5:55pm	UC Irvine (Crawford Hall)	Fastest
7:45am	San Ysidro Bus terminal	2h 35m	10:20am	Anaheim Regional Transportation Intermodal Center	No tags
7:00pm	San Ysidro Bus terminal	2h 35m	9:35pm	Anaheim Regional Transportation Intermodal Center	No tags
1:15am	San Ysidro Greyhound Bus Station	2h 30m	3:45am	Santa Ana E Santa Ana Blvd	No tags

Last refresh of the prices: Last Thursday at 4:51 PM PST.

Get from San Ysidro to Santa Ana

This route is served by bus only

The journey takes about 2 hours 45 minutes and with fares starting at just $24, it presents an excellent value for a comfortable ride.

19bus per day

2h 45mAverage Duration

96 milesDistance

4kgCO₂ emissions

Compare bus companies

Los Limousines

3.5/5261 reviews

Staff4.3

Timeliness2.8

Cleanliness3.9

Wifi2.8

FlixBus

3.5/511,244 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,359 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound San Ysidro Santa Ana recent customer reviews

Bus was two an hour and fifty minute late, and there was a foul smell from the sewage in the bathroom

Tlaloc C.

July 11, 2023

Excellent service and excellent value...same as earlier trip from Los Angeles to san Ysidro

Michael N.

December 4, 2019

Worst service.

Benjamin S.

August 21, 2018

Fronteras del Norte

3.5/53 reviews

Staff5

Timeliness1.7

Cleanliness5

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in San Ysidro and Santa Ana?

Stops in San Ysidro

A - San Ysidro Greyhound Bus Station

Stops in Santa Ana

A - Santa Ana Greyhound Bus Station

B - 602 S Main St

Frequently asked questions about traveling from San Ysidro, CA to Santa Ana, US by bus

What is the distance between San Ysidro and Santa Ana?
What are the departure and arrival stations when taking the bus from San Ysidro to Santa Ana?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/07

$28

11/08

$23

Today

$22

11/10

No data

11/11

$17

11/12

No data

11/13

$18

11/14

$18

The cheapest trip from San Ysidro, CA to Santa Ana, US was searched and found on Nov 11, 2025 with a price of $17

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Santa Ana, US, as early as possible.

You can expect to pay from $17 to $57 for a bus ticket from San Ysidro, CA to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $17 which is on 2025-11-11.

Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

Top traveled bus routes

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Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.