Bus from San Ysidro, CA to Santa Ana, US: Tickets & Schedules

Next bus departures

Next departures for San Ysidro to Santa Ana on December 10
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.Bus
San Ysidro Bus terminal
Santa Ana Bus StationCheapest
Los LimousinesBus
San Ysidro Greyhound Bus Station
Santa Ana E Santa Ana BlvdFastest
Greyhound Lines, Inc.Bus
San Ysidro Bus terminal
Anaheim Regional Transportation Intermodal CenterNo tags
Los LimousinesBus
San Ysidro Greyhound Bus Station
Santa Ana E Santa Ana BlvdNo tags
Greyhound Lines, Inc.Bus
San Ysidro Bus terminal
Santa Ana Bus StationNo tags

Last refresh of the prices: Yesterday at 11:20 PM PST.

Get from San Ysidro to Santa Ana

This route is served by bus only

The journey takes about 2 hours 50 minutes, and with fares starting at just $38, it presents an excellent value for a comfortable ride.

17bus per day
2h 50mAverage Duration
155 kmDistance
4kgCO₂ emissions

Frequently asked questions about travelling from San Ysidro, CA to Santa Ana, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from San Ysidro to Santa Ana?

    The cheapest bus tickets from San Ysidro to Santa Ana start from $38. The average price for this route is around $64. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from San Ysidro to Santa Ana?

    The average bus travel time from San Ysidro to Santa Ana is 2h 50m, covering a distance of 155 km. The quickest bus can get you there in 2h and is operated by Los Limousines.

  3. Which bus companies service the San Ysidro to Santa Ana route?

    Several major bus companies operate on this route with 17 buses available per day, including services from Los Limousines, FlixBus, Greyhound, Fronteras del Norte.

  4. What are the earliest and latest departure times for the bus from San Ysidro to Santa Ana?

    The earliest bus departs from San Ysidro to Santa Ana at 12:00am. And the latest bus departs at 10:00pm.

  5. What are the CO₂ emissions for the bus trip from San Ysidro to Santa Ana?

    A bus trip from San Ysidro to Santa Ana generates an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

  6. What is the best bus company from San Ysidro to Santa Ana?

    According to Busbud customers, the highest-rated bus company on this route is Fronteras del Norte, with an average rating of 3.6 out of 5 stars based on 3 reviews.

  7. Which bus company has the best Wi-Fi from San Ysidro to Santa Ana?

    Based on Busbud reviews, the bus company Los Limousines has the highest Wi-Fi rating with a score of 2.8.

  8. Which bus company has the best on-time performance from San Ysidro to Santa Ana?

    According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from San Ysidro to Santa Ana?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Fronteras del Norte, with a cleanliness rating of 5.0 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12-07
$42
12-08
$41
Today
$40
12-10
$32
12-11
$31
12-12
$31
12-13
$30
12-14
$30
busbud logoThe cheapest trip from San Ysidro, CA to Santa Ana, US was searched and found on Dec 13, 2025 with a price of $30

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Santa Ana, US, as early as possible.

You can expect to pay from $30 to $58 for a bus ticket from San Ysidro, CA to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $30 which is on 2025-12-13.

Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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