How much does a bus ticket from St. Louis to Chicago cost?

The bus ticket price from St. Louis to Chicago starts at US$35. The best way to find cheap bus tickets from St. Louis to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the bus ride from St. Louis to Chicago?

The average travel time between St. Louis and Chicago is around 6h 25m, although the fastest bus will take about 4h 50m. This is the time it takes to travel the 419 km that separates the two cities.

How many daily bus connections are there between St. Louis and Chicago?

The number of buses from St. Louis to Chicago can differ depending on the day of the week. On average, there are 7 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

Which bus companies travel from St. Louis to Chicago?

When taking the bus from St. Louis to Chicago, you can travel comfortably and safely with FlixBus, Greyhound, Amtrak.

Bus St. Louis to Chicago from US$35 | Refundable Tickets

Next departures

Next departures from St. Louis to Chicago on 3 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Next departures from St. Louis to Chicago on 4 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
08:45	Gateway Station	11h 25m	20:10	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Next departures from St. Louis to Chicago on 5 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
02:00	Gateway Station	11h 40m	13:40	Chicago 95Th & Dan Ryan	Cheapest
13:55	Gateway Station	9h 5m	23:00	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
02:00	Gateway Station	12h 35m	14:35	Downtown Greyhound Station	No tags
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags

Next departures from St. Louis to Chicago on 6 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	Cheapest
23:30	Gateway Station	5h 50m	05:20	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
13:55	Gateway Station	9h 40m	23:35	Downtown Greyhound Station	No tags
23:30	Gateway Station	6h 15m	05:45	Downtown Greyhound Station	No tags

Next departures from St. Louis to Chicago on 7 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
23:30	Gateway Station	5h 50m	05:20	Chicago 95Th & Dan Ryan	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Next departures from St. Louis to Chicago on 8 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags
23:30	Gateway Station	6h 15m	05:45	Downtown Greyhound Station	No tags

Next departures from St. Louis to Chicago on 9 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Next departures from St. Louis to Chicago on 10 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
09:30	Gateway Station	7h	16:30	Downtown Greyhound Station	Cheapest
16:00	Gateway Station	5h 50m	21:50	Chicago 95Th & Dan Ryan	Fastest
23:00	Gateway Station	10h 15m	09:15	Chicago (Union Station), IL	No tags
16:00	Gateway Station	6h 15m	22:15	Downtown Greyhound Station	No tags
02:00	Gateway Station	12h 10m	14:10	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Today at 6:25 PM CST.

Compare 2 ways to travel from St. Louis to Chicago

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 5 minutes and with fares starting at just US$30, it presents an excellent value for a comfortable ride.

4train per day

5h 5mAverage duration

423 kmDistance

38kgCO₂ emissions

	Average price	Average duration	CO₂ emissions
Bus	Average priceUS$35 - US$187	Average duration6h 25m	CO₂ emissions 10kg CO₂e
Train	Average priceUS$30 - US$238	Average duration5h 5m	CO₂ emissions 38kg CO₂e

Bus St. Louis to Chicago: Trip Overview

Average ticket priceUS$48

Average bus trip duration6h 25m

Number of daily buses7

Earliest bus departure02:00

Distance408 km

Latest bus departure23:30

Compare bus companies

FlixBus

3.5/511 161 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

Greyhound

3.5/587 348 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

According to 27 reviews, Greyhound received a 3.1-star rating for this journey. Travellers were especially satisfied with the temperature and the departure location, but some complained about the value for money. Greyhound ticket prices on this trip start at US$35

Greyhound St. Louis Chicago recent customer reviews

My trip was changed then cancelled and the next bus took 2 hrs . My connection to complete my trip made me arrive at my final destination at 4 am to an empty station where I couldn't get any assistance. Couldn't get a taxi at that hour there. It was a very horrible experience.

Raydell W.

3 July 2023

My first time from along time to many stops little confusing if we were close or what time we really will be in Chicago in all Ok!

Shelia S.

18 July 2019

Very professional and courteous. Actually, quite a bit more professional and less stressful than air travel presently. Pleasantly surprised!

Laura M.

18 October 2018

Amtrak

4/55 562 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

WiFi3.6

Users have praised the service for being on time, comfortable, and convenient with friendly conductors. However, there were concerns about inconsistent behavior from staff towards passengers of different races during ticket checks and upon arrival.

Amtrak St. Louis Chicago recent customer reviews

Smooth ride. The man who did our tickets from St. Louis we noticed after checking white people's tickets he said thanks and have a great day. To black people he said nothing. Then upon arriving in Chicago that man offered no one a hand down or said goodbye.

Yvonne H.

27 September 2024

Fabulous! Train is the way to go for this distance!! On time, comfortable, friendly conductors, and SO convenient!

Kendra H.

3 April 2024

Good but train was cancelled and coming with bus. I pay too much money

Anshul P.

23 December 2024

Burlington Trailways

4/520 reviews

Staff5

Timeliness5

Cleanliness5

WiFi5

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

St. Louis to Chicago Bus

Busbud helps you find a bus from St. Louis to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Where are the popular stops in St. Louis and Chicago?

Stops in St. Louis

A - Gateway Station

Stops in Chicago

A - Downtown Greyhound Station

B - Chicago O'Hare International Airport

C - Polk St & Canal St

D - Tornado Bus S Kedzie Ave

E - Cumberland CTA

F - Turimex California Ave

Frequently asked questions on the trip St. Louis - Chicago

How much does a bus ticket from St. Louis to Chicago cost?
The bus ticket price from St. Louis to Chicago starts at US$35. The best way to find cheap bus tickets from St. Louis to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from St. Louis to Chicago?
The average travel time between St. Louis and Chicago is around 6h 25m, although the fastest bus will take about 4h 50m. This is the time it takes to travel the 419 km that separates the two cities.
How many daily bus connections are there between St. Louis and Chicago?
The number of buses from St. Louis to Chicago can differ depending on the day of the week. On average, there are 7 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from St. Louis to Chicago?
When taking the bus from St. Louis to Chicago, you can travel comfortably and safely with FlixBus, Greyhound, Amtrak.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

31/10

US$57

01/11

US$48

Today

US$59

03/11

US$46

04/11

US$41

05/11

US$45

06/11

US$35

07/11

US$40

The cheapest trip from St. Louis to Chicago was searched and found on 06 Nov 2025 with a price of US$35

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Chicago as early as possible.

You can expect to pay from US$35 to US$319 for a bus ticket from St. Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$35, which is on 2025-11-06.

Usually Greyhound, Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Chicago!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Chicago.

Make a music playlist for your bus ride from St. Louis to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to St. Louis by bus?

Bus from Chicago to St. Louis

You can also go to Chicago by train

Train from St. Louis to Chicago

Top travelled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Find coaches from St. Louis to Chicago