Find coaches from St. Louis to Chicago

Next departures

Next departures from St. Louis to Chicago on 9 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Gateway Station
Downtown Greyhound StationCheapest
FlixBus
Gateway Station
Chicago 95Th & Dan RyanFastest
Amtrak
Gateway Station
Chicago (Union Station), ILNo tags
FlixBus
Gateway Station
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.
Gateway Station
537-517 W. Jackson BlvdNo tags

Last refresh of the prices: Today at 12:06 CDT.

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Compare 2 ways to travel from St. Louis to Chicago

Bus
Average priceUS$35 - US$187Average duration6h 15m
11kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average priceUS$30 - US$98Average duration5h 5m
38kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from St. Louis to Chicago

Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 5 minutes and with fares starting at just US$30, it presents an excellent value for a comfortable ride.

5train per day
5h 5mAverage duration
US$30Cheapest ticket
38kgCO₂ emissions

Bus St. Louis to Chicago: Trip Overview

Average ticket priceUS$46
Average bus trip duration6h 15m
Number of daily buses7
Earliest bus departure02:00
Distance262 miles
Latest bus departure23:30

St. Louis to Chicago Bus

Busbud helps you find a bus from St. Louis to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - Chicago

  1. How far is Chicago from St. Louis by coach?

    The distance between St. Louis and Chicago by coach is approximately 260 miles (419 km).

  2. Is there a way to reach Chicago from St. Louis without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/10
US$46
07/10
US$41
Today
US$46
09/10
US$46
10/10
US$43
11/10
US$40
12/10
US$40
13/10
US$40
busbud logoThe cheapest trip from St. Louis to Chicago was searched and found on 11 Oct 2025 with a price of US$40

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Chicago as early as possible.

You can expect to pay from US$40 to US$270 for a bus ticket from St. Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$40, which is on 2025-10-11.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Chicago!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Chicago.

Make a music playlist for your bus ride from St. Louis to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to St. Louis by bus?

Bus from Chicago to St. Louis

You can also go to Chicago by train

Train from St. Louis to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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