Next departures for St. Louis to Chicago on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
Chicago (Union Station), IL
No tags
Next departures for St. Louis to Chicago on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Chicago 95Th & Dan Ryan
CheapestFastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures for St. Louis to Chicago on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Chicago 95Th & Dan Ryan
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures for St. Louis to Chicago on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures for St. Louis to Chicago on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Next departures for St. Louis to Chicago on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures for St. Louis to Chicago on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures for St. Louis to Chicago on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Last refresh of the prices: Today at 5:06 AM CST.
Compare 2 ways to go from St. Louis to Chicago
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Chicago. The journey takes about 5 hours 5 minutes and with fares starting at just $30, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound St. Louis Chicago recent customer reviews
My trip was changed then cancelled and the next bus took 2 hrs . My connection to complete my trip made me arrive at my final destination at 4 am to an empty station where I couldn't get any assistance. Couldn't get a taxi at that hour there. It was a very horrible experience.
1 out of 5 stars
Raydell W.
My first time from along time to many stops little confusing if we were close or what time we really will be in Chicago in all Ok!
3 out of 5 stars
Shelia S.
Very professional and courteous. Actually, quite a bit more professional and less stressful than air travel presently. Pleasantly surprised!
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travelers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at $187
Users have praised the service for being on time, comfortable, and convenient with friendly conductors. However, there were concerns about inconsistent behavior from staff towards passengers of different races during ticket checks and upon arrival.
Amtrak St. Louis Chicago recent customer reviews
Smooth ride. The man who did our tickets from St. Louis we noticed after checking white people's tickets he said thanks and have a great day. To black people he said nothing. Then upon arriving in Chicago that man offered no one a hand down or said goodbye.
4 out of 5 stars
Yvonne H.
Fabulous! Train is the way to go for this distance!! On time, comfortable, friendly conductors, and SO convenient!
5 out of 5 stars
Kendra H.
Good but train was cancelled and coming with bus. I pay too much money
Frequently asked questions about traveling from St. Louis to Chicago by bus
What is the travel distance from St. Louis to Chicago?
About 260 miles (419 km) separate St. Louis and Chicago.
What are the departure and arrival stations when taking the bus from St. Louis to Chicago?
The majority of buses traveling from St. Louis to Chicago start their journey at Gateway Station and wind up at Downtown Greyhound Station. These are the main pick-up and drop-off locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Chicago?
Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Museum of Science and Industry, The Field Museum, Chicago Shakespeare Theater on Navy Pier, Lincoln Park Conservatory and Shedd Aquarium.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$99
11/23
$83
Today
$61
11/25
$59
11/26
$57
11/27
$45
11/28
$44
11/29
$52
The cheapest trip from St. Louis to Chicago was searched and found on Nov 28, 2025 with a price of $44
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Chicago, as early as possible.
You can expect to pay from $44 to $328 for a bus ticket from St. Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $44 which is on 2025-11-28.
Usually Greyhound, Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from St. Louis to Chicago was searched and found on Nov 28, 2025 with a price of $44
