Find coaches from St. Louis to San Diego, CA, US

Next departures

Next departures from St. Louis to San Diego on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Gateway Station
Downtown SD (Seaport)Cheapest
Greyhound Lines, Inc. + FlixBus
Gateway Station
UCSD Health La Jolla StationFastest
Greyhound Lines, Inc. + FlixBus
Gateway Station
San Diego (Old Town-FlixBus)No tags
Greyhound Lines, Inc.
Gateway Station
Greyhound Bus StopNo tags
Greyhound Lines, Inc. + FlixBus
Gateway Station
San Diego (Old Town-FlixBus)No tags

Last refresh of the prices: Today at 11:43 AM CDT.

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Compare 2 ways to travel from St. Louis to San Diego

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 1 day, 23 hours 40 minutes and with fares starting at just US$136, it presents an excellent value for a comfortable ride.

10bus per day
1d 23hAverage duration
2514 kmDistance
63kgCO₂ emissions
Bus
Average priceUS$136 - US$495Average duration1d 23h
63kg CO₂e
Train
Average priceUS$202 - US$569Average duration2d 8h
229kg CO₂e

Bus St. Louis to San Diego, CA, US: Trip Overview

Average ticket priceUS$230
Average bus trip duration1d 23h
Number of daily buses10
Earliest bus departure01:20
Distance2514 km
Latest bus departure23:30

St. Louis to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to San Diego.

We make sure you can find a bus service from St. Louis to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - San Diego, CA, US

  1. How much does a bus ticket from St. Louis to San Diego cost?

    The bus ticket price from St. Louis to San Diego starts at US$136. The best way to find cheap bus tickets from St. Louis to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from St. Louis to San Diego?

    The average travel time between St. Louis and San Diego is around 1d 23h, although the fastest bus will take about 1d 18h. This is the time it takes to travel the 2516 km that separates the two cities.

  3. How many daily bus connections are there between St. Louis and San Diego?

    The number of buses from St. Louis to San Diego can differ depending on the day of the week. On average, there are 10 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to San Diego by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from St. Louis to San Diego?

    When taking the bus from St. Louis to San Diego, you can travel comfortably and safely with Greyhound, FlixBus.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$377
29/10
No data
Today
No data
31/10
US$423
01/11
No data
02/11
No data
03/11
No data
04/11
No data
busbud logoThe cheapest trip from St. Louis to San Diego, CA, US was searched and found on 28 Oct 2025 with a price of US$377

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Diego, CA, US as early as possible.

You can expect to pay from US$377 to US$423 for a bus ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$423, which is on 2025-10-31.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to San Diego.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Diego.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from St. Louis to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from San Diego, CA, US to St. Louis

You can also go to San Diego, CA, US by train

Train from St. Louis to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

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