Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Greyhound Bus Stop | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Gateway Station | UCSD Health La Jolla Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Gateway Station | San Diego (Old Town-FlixBus) | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Gateway Station | San Diego (Old Town-FlixBus) | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Gateway Station | UCSD Health La Jolla Station | No tags |
Last refresh of the prices: Yesterday at 6:26 PM CST.
Compare 2 ways to go from St. Louis to San Diego
Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 1 day, 23 hours 40 minutes, and with fares starting at just $226, it presents an excellent value for a comfortable ride.
Where are the popular stops in St. Louis and San Diego?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Frequently asked questions about travelling from St. Louis to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to San Diego?
The cheapest bus tickets from St. Louis to San Diego start from $226. The average price for this route is around $502. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to San Diego?
The average bus travel time from St. Louis to San Diego is 1d 23h, covering a distance of 2514 km. The quickest bus can get you there in 1d 18h and is operated by Greyhound.
Which bus companies service the St. Louis to San Diego route?
What are the earliest and latest departure times for the bus from St. Louis to San Diego?
The earliest bus departs from St. Louis to San Diego at 1:00am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from St. Louis to San Diego?
A bus trip from St. Louis to San Diego generates an estimated 63 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from St. Louis to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from St. Louis to San Diego?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from St. Louis to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from St. Louis to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to San Diego, CA, US was searched and found on Dec 5, 2025 with a price of $318To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Diego, CA, US, as early as possible.
You can expect to pay from $318 to $679 for a bus ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $318 which is on 2025-12-05.
What's the cheapest way to go from St. Louis to San Diego, CA, US?
The bus is the cheapest travel choice for this destination
