Find coaches from St. Louis to San Diego, CA, US

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Wed16 Jul
Thu17 Jul
Fri18 Jul
from US$150
Sat19 Jul
Sun20 Jul
Mon21 Jul
Tue22 Jul
Wed23 Jul

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 18 July at
    Departure city: St. Louis
    Departure location: Saint Louis (Lambert Field)
    Arrival time: 20 July at
    Destination city: San Diego
    Destination location: 5716 Hardy Ave
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 18 July at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 19 July at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 18 July at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 19 July at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 18 July at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 19 July at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 18 July at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 20 July at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from St. Louis to San Diego

Bus
Average priceUS$105 - US$416Average duration2d 1h
63kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$219 - US$389Average duration2d 8h
229kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to San Diego

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 1 hour 10 minutes and with fares starting at just US$105, it presents an excellent value for a comfortable ride.

11bus per day
2d 1hAverage duration
US$105Cheapest ticket
63kgCO₂ emissions

Bus St. Louis to San Diego: Trip Overview

Average ticket priceUS$190
Average bus trip duration2d 1h
Number of daily buses11
Earliest bus departure01:35
Distance1557 miles
Latest bus departure16:30

St. Louis to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to San Diego.

We make sure you can find a bus service from St. Louis to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - San Diego, CA, US

  1. How far is San Diego from St. Louis by coach?

    The journey from St. Louis to San Diego by coach covers an approximate distance of 1560 miles (2516 km).

  2. Is there a way to reach San Diego from St. Louis without flying?

    To travel from St. Louis to San Diego without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/07
No data
13/07
US$215
Today
No data
15/07
US$161
16/07
US$139
17/07
No data
18/07
US$166
19/07
No data
busbud logoThe cheapest trip from St. Louis to San Diego was searched and found on 16 Jul 2025 with a price of US$139

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Diego as early as possible.

You can expect to pay from US$139 to US$234 for a bus ticket from St. Louis to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at US$139, which is on 2025-07-16.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to San Diego.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Diego.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from St. Louis to San Diego?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from St. Louis to San Diego

You can also go to San Diego, CA, US by train

Train from St. Louis to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

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Popular Buses Connecting St. Louis

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Popular Buses Connecting San Diego

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