Bus Tickets from St. Louis to San Diego, CA, US

Previously seen trips

Next departures for St. Louis to San Diego on October 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
St Louis, MO
Downtown SD (Seaport)No tags
Greyhound + FlixBus
Gateway Station
UCSD Health La Jolla StationNo tags
FlixBus + Greyhound
Gateway Station
San Diego (Old Town-FlixBus)No tags
Greyhound + FlixBus
Gateway Station
Downtown SD (Seaport)No tags
Greyhound
Gateway Station
Greyhound Bus StopNo tags

Accepted payments

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  • Klarna (Pay over time)
  • Google Pay

Bus St. Louis to San Diego, CA, US: Trip Overview

Average ticket price$187
Average bus trip duration2d 1h
Number of daily buses13
Earliest bus departure1:20am
Distance1551 miles (2501 km)
Latest bus departure11:30pm

St. Louis to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to San Diego.

We make sure you can find a bus service from St. Louis to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St. Louis - San Diego, CA, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/11
$129
10/12
$322
Today
No data
10/14
$157
10/15
No data
10/16
No data
10/17
No data
10/18
No data
busbud logoThe cheapest trip from St. Louis to San Diego, CA, US was searched and found on Oct 11, 2025 with a price of $129

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Diego, CA, US, as early as possible.

You can expect to pay from $129 to $322 for a bus ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $157 which is on 2025-10-14.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to San Diego.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Diego.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to St. Louis by bus?

Bus from San Diego, CA, US to St. Louis

You can also go to San Diego, CA, US by train

Train from St. Louis to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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Popular Buses Connecting St. Louis

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Popular Buses Connecting San Diego

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