Find coaches from Syracuse, US to Greenville, SC

Next bus departures

Next departures from Syracuse to Greenville on 14 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
1116 Woodruff RdCheapest
FlixBusBus
Syracuse (Regional Transportation Center)
1116 Woodruff RdFastest

Last refresh of the prices: 11/07/2025 EST.

Compare 2 ways to travel from Syracuse to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 22 hours 20 minutes and with fares starting at just R 1 844, it presents an excellent value for a comfortable ride.

3bus per day
22h 20mAverage duration
1059 kmDistance
26kgCO₂ emissions
Average priceR 1 844 - R 4 684Average duration22h 20m
26kg CO₂e
Average priceR 3 524 - R 4 050Average duration22h 18m
97kg CO₂e

Frequently asked questions about travelling from Syracuse, US to Greenville, SC by bus

  1. How much does a bus ticket from Syracuse to Greenville cost?

    The bus ticket price from Syracuse to Greenville starts at R 1 844. The best way to find cheap bus tickets from Syracuse to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Syracuse to Greenville?

    The average travel time between Syracuse and Greenville is around 22h 20m, although the fastest bus will take about 20h 55m. This is the time it takes to travel the 1060 km that separates the two cities.

  3. How many daily bus connections are there between Syracuse and Greenville?

    The number of buses from Syracuse to Greenville can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Syracuse to Greenville by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Syracuse to Greenville?

    When taking the bus from Syracuse to Greenville, you can travel comfortably and safely with FlixBus, Greyhound.

  5. What are the departure and arrival stations when taking the bus from Syracuse to Greenville?

    Buses travelling between Syracuse and Greenville leave from Regional Transportation Center or Syracuse Airport and arrive at Guadalajara Supermarket Bus Stop, Greenville Bus Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/11
R 3 314
13/11
R 2 051
Today
R 2 130
15/11
R 2 051
16/11
R 2 157
17/11
R 2 034
18/11
No data
19/11
R 1 990
busbud logoThe cheapest trip from Syracuse, US to Greenville, SC was searched and found on 19 Nov 2025 with a price of R 1 990

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC as early as possible.

You can expect to pay from R 1 990 to R 3 471 for a bus ticket from Syracuse, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 990, which is on 2025-11-19.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Syracuse, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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