Bus Tickets from Syracuse, US to Greenville, SC

Next bus departures

Next departures for Syracuse to Greenville on November 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
1116 Woodruff RdCheapest
FlixBusBus
Syracuse (Regional Transportation Center)
1116 Woodruff RdFastest

Last refresh of the prices: 2025-11-07 EST.

Compare 2 ways to go from Syracuse to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 22 hours 20 minutes, and with fares starting at just $152, it presents an excellent value for a comfortable ride.

3bus per day
22h 20mAverage Duration
1059 kmDistance
26kgCO₂ emissions
Bus
Average Price$152 - $385Average Duration22h 20m
26kg CO₂e
Train
Average Price$290 - $333Average Duration22h 18m
97kg CO₂e

Frequently asked questions about travelling from Syracuse, US to Greenville, SC by bus

  1. What is the distance between Syracuse and Greenville?

    The distance covered from Syracuse to Greenville is 1060 km (658 miles).

  2. What are the departure and arrival locations for buses traveling from Syracuse to Greenville?

    Buses traveling this route start their trip at Regional Transportation Center, in Syracuse, and end it at Guadalajara Supermarket Bus Stop, in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-12
$272
11-13
$169
Today
$175
11-15
$169
11-16
$177
11-17
$167
11-18
No data
11-19
$164
busbud logoThe cheapest trip from Syracuse, US to Greenville, SC was searched and found on Nov 19, 2025 with a price of $164

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC, as early as possible.

You can expect to pay from $164 to $285 for a bus ticket from Syracuse, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $164 which is on 2025-11-19.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Syracuse, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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