Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Syracuse (Regional Transportation Center) | 1116 Woodruff Rd | Cheapest | ||||
| Bus | Syracuse (Regional Transportation Center) | 1116 Woodruff Rd | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Syracuse (Regional Transportation Center) | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Yesterday at 3:24 PM EST.
Compare 2 ways to go from Syracuse to Greenville
Among the sustainable travel choices, the train stands out as a good way to reach Greenville. The journey takes about 22 hours 18 minutes, and with fares starting at just $285, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$162 - $485 | Average Duration22h 15m | 26kg CO₂e | ||
Train | Average Price$285 - $328 | Average Duration22h 18m | 97kg CO₂e |
Where are the popular stops in Syracuse and Greenville?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Frequently asked questions about travelling from Syracuse, US to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Syracuse to Greenville?
The cheapest bus tickets from Syracuse to Greenville start from $162. The average price for this route is around $336. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Greenville?
The average bus travel time from Syracuse to Greenville is 22h 15m, covering a distance of 1059 km. The quickest bus can get you there in 21h 50m and is operated by FlixBus.
Which bus companies service the Syracuse to Greenville route?
What are the earliest and latest departure times for the bus from Syracuse to Greenville?
The earliest bus departs from Syracuse to Greenville at 9:25am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Greenville?
A bus trip from Syracuse to Greenville generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Syracuse to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11828 reviews.
Which bus company has the best Wi-Fi from Syracuse to Greenville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Syracuse to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Greenville, SC was searched and found on Jan 8, 2026 with a price of $207To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC, as early as possible.
You can expect to pay from $207 to $231 for a bus ticket from Syracuse, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $207 which is on 2026-01-08.
