Find coaches from Syracuse, US to Greenville, SC

Next bus departures

Next departures from Syracuse to Greenville on 14 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
1116 Woodruff RdCheapest
FlixBusBus
Syracuse (Regional Transportation Center)
1116 Woodruff RdFastest

Last refresh of the prices: 07/11/2025 EST.

Compare 2 ways to travel from Syracuse to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 22 hours 20 minutes and with fares starting at just £82, it presents an excellent value for a comfortable ride.

3bus per day
22h 20mAverage duration
657 milesDistance
26kgCO₂ emissions
Bus
Average price£82 - £209Average duration22h 20m
26kg CO₂e
Train
Average price£157 - £181Average duration22h 18m
97kg CO₂e

Frequently asked questions about travelling by bus from Syracuse, US to Greenville, SC

  1. How far is Greenville from Syracuse by coach?

    The distance between Syracuse and Greenville by coach is approximately 658 miles (1060 km).

  2. What is the best way to go from Syracuse to Greenville without flying?

    You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/11
£148
13/11
£92
Today
£95
15/11
£92
16/11
£96
17/11
£91
18/11
No data
19/11
£89
busbud logoThe cheapest trip from Syracuse, US to Greenville, SC was searched and found on 19 Nov 2025 with a price of £89

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Greenville, SC as early as possible.

You can expect to pay from £89 to £155 for a bus ticket from Syracuse, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £89, which is on 2025-11-19.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Syracuse, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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