Is there a way to reach Greenville from Syracuse without flying?

You have the option of traveling from one city to the other by either bus or train. Both are convenient and sustainable ways to travel to Greenville. You can also use carpool services and share a car ride with other travelers.

How long does it take to get to Greenville from Syracuse by bus?

The travel time from Syracuse to Greenville is about 21h, although the fastest bus will take 20h 20m, on average. This is the time it takes to travel the 658 miles (1060 km) that separate the two cities.

What is the distance between Syracuse and Greenville?

About 658 miles (1060 km) separate Syracuse and Greenville.

What are the departure and arrival stations when taking the bus from Syracuse to Greenville?

If you're headed to Greenville from Syracuse, chances are that your bus will leave from Syracuse Airport and arrive at Guadalajara Supermarket Bus Stop. These are the primary departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

What is the most cost-effective way to get from Syracuse to Greenville?

The cheapest way to travel this route is by bus. The lowest price for the bus on this route is $89.

What is the ticket price for the bus trip from Syracuse to Greenville?

The average price of a one-way ticket from Syracuse to Greenville is $144. In the last 30 days, the prices ranged from $89 to $259, so it's good to do your research before booking.

Is it possible to travel by overnight bus from Syracuse to Greenville?

Yes, you can take a night bus to go from Syracuse to Greenville. Make sure to pack a blanket and a snack to make your trip more comfortable.

Syracuse, US to Greenville (SC) Bus Tickets

TodayMay 17

from $188

TomorrowMay 18

MonMay 19

TueMay 20

WedMay 21

ThuMay 22

FriMay 23

SatMay 24

Cheap buses leaving today

One passenger / one way

This trip is recommended because it is: Cheapest + Fastest
Departure time: May 17 at 3:00pm
Departure city: Syracuse
Departure location: Syracuse (Regional Transportation Center)
Arrival time: May 18 at 1:15pm
Destination city: Greenville
Destination location: 1116 Woodruff Rd
Operated by: FlixBus
Vehicle: BusDuration: 22h 15m
Departure time: May 17 at 9:00pm
Departure city: Syracuse
Departure location: Syracuse (Regional Transportation Center)
Arrival time: May 18 at 7:40pm
Destination city: Greenville
Destination location: 1116 Woodruff Rd
Operated by: Greyhound Lines, Inc. + FlixBus
Greyhound Lines, Inc. + FlixBus
Vehicle: BusDuration: 22h 40m

Accepted payments

Compare 2 ways to go from Syracuse to Greenville.

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$89 - $259	Average Duration21h	CO₂ emissions 26kg CO₂e5 out of 5 stars	CheapestFastestMost eco-friendly
Train	Average Price$201 - $231	Average Duration22h 18m	CO₂ emissions 97kg CO₂e1 out of 5 stars

Busbud recommends taking the bus from Syracuse to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 21 hours and with fares starting at just $89, it presents an excellent value for a comfortable ride.

3bus per day

21hAverage Duration

$89Cheapest ticket

26kgCO₂ emissions

Bus Syracuse to Greenville: Trip Overview

Average ticket price$144

Average bus trip duration21h

Number of daily buses3

Earliest bus departure12:00pm

Distance657 miles (1059 km)

Latest bus departure9:00pm

Compare bus companies

FlixBus

3.5/58,642 reviews

Staff4.1

Timeliness4

Cleanliness4.1

Wifi2.6

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

FlixBus Syracuse Greenville recent customer reviews

It depended on the driver, as well as the cleanliness of each individual bus.

Marie S.

July 28, 2023

Greyhound

3.5/586,984 reviews

Staff3.6

Timeliness2.8

Cleanliness3.3

Wifi2.3

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, Greyhound, Los Limousines, Tornado Bus, Valley Transit, Tufesa, Wanda Coach

Syracuse to Greenville Bus

Busbud helps you find a bus from Syracuse to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Syracuse to Greenville.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Syracuse, we help you find what you're looking for based on how much of a budget you have.

Where are the popular stops in Syracuse and Greenville?

Stops in Syracuse

A - Syracuse Airport

B - Regional Transportation Center

C - Syracuse University

D - Syracuse University - Lyman Hall

E - New York State Fairgrounds

F - Syracuse, NY

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Frequently asked questions for your trip Syracuse - Greenville

Is there a way to reach Greenville from Syracuse without flying?
How long does it take to get to Greenville from Syracuse by bus?
What is the distance between Syracuse and Greenville?
What are the departure and arrival stations when taking the bus from Syracuse to Greenville?
What is the most cost-effective way to get from Syracuse to Greenville?
What is the ticket price for the bus trip from Syracuse to Greenville?
Is it possible to travel by overnight bus from Syracuse to Greenville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

05/15

No data

05/16

$96

Today

$174

05/18

$143

05/19

$140

05/20

No data

05/21

No data

05/22

No data

The cheapest trip from Syracuse to Greenville was searched and found on May 16, 2025 with a price of $96

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse to Greenville, as early as possible.

You can expect to pay from $96 to $224 for a bus ticket from Syracuse to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $140 which is on 2025-05-19.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Syracuse and Greenville!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Syracuse to Greenville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Syracuse to Greenville.

Make a music playlist for your bus ride from Syracuse to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from Syracuse to Greenville?

The bus is the cheapest travel choice for this destination

Vehicle Type	Travel Time	Avg Price	Daily Departures
Vehicle TypeBus	Travel Time21h	Avg Price$144	Daily Departures3
Vehicle TypeTrain	Travel Time22h 18m	Avg Price$201	Daily Departures1

Will you be returning to Syracuse by bus?

Bus from Syracuse to Greenville

You can also go to Greenville by train

Train from Syracuse to Greenville

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Bus Tickets from Syracuse, NY to Greenville, SC

Cheap buses leaving today

One passenger / one way

Compare 2 ways to go from Syracuse to Greenville.

Bus Syracuse to Greenville: Trip Overview

Compare bus companies

FlixBus Syracuse Greenville recent customer reviews

Syracuse to Greenville Bus

Where are the popular stops in Syracuse and Greenville?

Frequently asked questions for your trip Syracuse - Greenville

Is there a way to reach Greenville from Syracuse without flying?

How long does it take to get to Greenville from Syracuse by bus?

What is the distance between Syracuse and Greenville?

What are the departure and arrival stations when taking the bus from Syracuse to Greenville?

What is the most cost-effective way to get from Syracuse to Greenville?

What is the ticket price for the bus trip from Syracuse to Greenville?

Is it possible to travel by overnight bus from Syracuse to Greenville?

Find cheapest prices for buses

About Bus Travel

Bus Travel Tips

Did you know?

What's the cheapest way to go from Syracuse to Greenville?

Will you be returning to Syracuse by bus?

You can also go to Greenville by train

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

People from around the world trust Busbud

Popular Buses Connecting Syracuse

Buses Leaving from Syracuse

Buses Going to Syracuse

Popular Buses Connecting Greenville

Buses Leaving from Greenville

Buses Going to Greenville

Popular routes in this country

Popular airport transfers