Next bus departures

Next departures for Brno to Brussels on September 3
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:20pm	Hotelu Grand	22h 55m	6:15pm	Brussels North Train Station	Cheapest
Bus	7:40am	Hotelu Grand	16h 45m	12:25am	Brussels North Train Station	Fastest
Bus	1:30am	Hotelu Grand	23h 40m	1:10am	Brussels Airport BRU (Parking P14)	No tags
Bus	11:30am	Hotelu Grand	21h 55m	9:25am	Brussels Airport BRU (Parking P14)	No tags
Bus	2:10pm	Hotelu Grand	22h 20m	12:30pm	Brussels Airport BRU (Parking P14)	No tags
Bus	6:10pm	Hotelu Grand	1d	6:35pm	Brussels Airport BRU (Parking P14)	No tags
Bus	11:30pm	Hotelu Grand	1d 1h	1:10am	Brussels Airport BRU (Parking P14)	No tags
Bus	9:15am	Hotelu Grand	21h 30m	6:45am	Brussels North Train Station	No tags

Last refresh of the prices: Today at 8:41 AM CEST.

Compare 2 ways to go from Brno to Brussels

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 21 hours 20 minutes and with fares starting at just PLN 259, it presents an excellent value for a comfortable ride.

14bus per day

21h 20mAverage Duration

554 milesDistance

22kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average PricePLN 259 - PLN 892	Average Duration21h 20m	CO₂ emissions 22kg CO₂e
Train	Average PricePLN 1,026 - PLN 1,026	Average Duration13h 15m	CO₂ emissions 21kg CO₂e

Bus stations and stops in Brno and Brussels

Stops in Brno

A
Hotelu Grand
Benešova 603/2, Brno-město, 602 00 Brno-Brno-střed, Czech Republic
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B
Hlavní nádraží
Nádražní 418/1, Brno-město, 602 00 Brno-Brno-střed, Czechia
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C
Brno Bus Station
Brno Bus Station, ÚAN Zvonařka, 602 00 Brno-střed, Czechia
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D
ÚAN Zvonařka
Zvonařka 411, Trnitá, 602 00 Brno-Brno-střed, Czech Republic
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E
Židenice
Lazaretní 610/11, 615 00 Brno-Brno-Židenice, Czechia
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F
Vídeňská 98
Vídeňská 98, 619 00 Brno-jih, Czechia

Stops in Brussels

A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
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B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
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C
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
D
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
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Compare companies

FlixBus

3.5/515,466 reviews

Staff4.1

Timeliness4.0

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

RegioJet

4.1/51,105 reviews

Staff4.5

Timeliness4.0

Cleanliness4.3

Wifi3.7

BE bus companies:FlixBus, BlaBlaCar Bus, Deutsche Bahn, Sindbad, Ecolines, KLR Bus, RegioJet

Frequently asked questions about traveling from Brno to Brussels by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Brno to Brussels?
The cheapest bus tickets from Brno to Brussels start from PLN 259. The average price for this route is around PLN 512. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Brno to Brussels?
The average bus trip duration from Brno to Brussels is 21h 20m, covering a distance of 554 miles (893 km). The quickest bus can get you there in 16h and is operated by RegioJet.
Which bus companies service the Brno to Brussels route?
Several major bus companies operate on this route with 14 buses available per day, including services from FlixBus, RegioJet.
What is the earliest and latest departure time for the bus from Brno to Brussels?
The earliest bus departs from Brno to Brussels at 1:30am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Brno to Brussels?
A bus trip from Brno to Brussels generates an estimated 22.310825 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Brno to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1103 reviews.
Which bus company has the best Wi-Fi from Brno to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Brno to Brussels?
According to Busbud traveler reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 4.1 out of 5 stars.
Which bus company has the cleanest buses from Brno to Brussels?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

08/31

PLN 277

09/01

PLN 242

Today

No data

09/03

PLN 244

09/04

PLN 246

09/05

No data

09/06

No data

09/07

No data

The cheapest trip from Brno to Brussels was searched and found on Sep 1, 2026 with a price of PLN 242

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brno to Brussels, as early as possible.

You can expect to pay from PLN 242 to PLN 456 for a bus ticket from Brno to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at PLN 244 which is on 2026-09-03.