Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Hotelu Grand | Brussels Airport | No tags | ||||
| Bus | Hotelu Grand | Brussels-North (Gare du Nord) | No tags | ||||
| Bus | Hotelu Grand | Brussels Airport | No tags | ||||
| Bus | Hotelu Grand | Brussels South (Gare du Midi) | No tags | ||||
| Bus | Hotelu Grand | Brussels-North (Gare du Nord) | No tags |
Compare 2 ways to go from Brno to Brussels
Among the sustainable travel choices, the bus stands out as the good way to reach Brussels. The journey takes about 21 hours 50 minutes and with fares starting at just $65, it presents an excellent value for a comfortable ride.
Where are the popular stops in Brno and Brussels?
Stops in Brno
- ABenešova 603/2, Brno-město, 602 00 Brno-Brno-střed, Czech Republic
- BZvonařka 411, Trnitá, 602 00 Brno-Brno-střed, Czech Republic
- CNádražní 418/1, Brno-město, 602 00 Brno-Brno-střed, Czechia
- DBrno Bus Station, ÚAN Zvonařka, 602 00 Brno-střed, Czechia
- E
Ústřední hřbitov
Vídeňská 306/94, Štýřice, 639 00 Brno-Brno-střed, Czechia - F
Vídeňská 98
Vídeňská 98, 619 00 Brno-jih, Czechia
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Compare bus companies
Frequently asked questions about traveling from Brno to Brussels by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Brno to Brussels?
The cheapest bus tickets from Brno to Brussels start from $65. The average price for this route is around $106. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Brno to Brussels?
The average bus trip duration from Brno to Brussels is 21h 50m, covering a distance of 550 miles (886 km). The quickest bus can get you there in 16h and is operated by RegioJet.
Which bus companies service the Brno to Brussels route?
What is the earliest and latest departure time for the bus from Brno to Brussels?
The earliest bus departs from Brno to Brussels at 1:30am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Brno to Brussels?
A bus trip from Brno to Brussels generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Brno to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1057 reviews.
Which bus company has the best Wi-Fi from Brno to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Brno to Brussels?
According to Busbud traveller reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Brno to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Brno to Brussels was searched and found on Dec 9, 2025 with a price of $75To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brno to Brussels, as early as possible.
You can expect to pay from $75 to $78 for a bus ticket from Brno to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $75 which is on 2025-12-09.
What's the cheapest way to go from Brno to Brussels?
The bus is the cheapest travel choice for this destination
