Next departures for Brussels to Lyon on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Perrache
Cheapest
Bus
Brussels South (Gare du Midi)
Perrache
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Perrache
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels South (Gare du Midi)
Perrache
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels Airport
Perrache
No tags
Next departures for Brussels to Lyon on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels South (Gare du Midi)
Perrache
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels Airport
Perrache
No tags
Next departures for Brussels to Lyon on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels Airport
Perrache
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Next departures for Brussels to Lyon on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Cheapest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
Fastest
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Bus
Brussels-South (Gare du Midi)
Lyon - Perrache Bus Station
No tags
Last refresh of the prices: Today at 4:58 AM CET.
Compare 3 ways to go from Brussels to Lyon
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Lyon. The journey takes about 7 hours 40 minutes and with fares starting at just $55, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11143 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $27
Frequently asked questions about traveling from Brussels to Lyon by bus
What is the distance between Brussels and Lyon?
Brussels and Lyon are 353 miles (569 km) apart.
What are the departure and arrival stations when taking the bus from Brussels to Lyon?
If you're headed to Lyon from Brussels, chances are that your bus will depart from Brussels South (Gare du Midi) and arrive at Lyon Airport. These are the most popular departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Lyon?
Once in Lyon, you can start exploring the city and discover its surroundings. The top sights and things to do are Opéra de Lyon, La Place des Terreaux/Bartholdi Fountain, Parc de la Tête d'Or, The Old Town and Musée des Tissus.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
$69
11/20
$80
Today
$52
11/22
$29
11/23
$48
11/24
$31
11/25
$34
11/26
$34
The cheapest trip from Brussels to Lyon was searched and found on Nov 22, 2025 with a price of $29
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Lyon, as early as possible.
You can expect to pay from $29 to $133 for a bus ticket from Brussels to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $29 which is on 2025-11-22.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Brussels to Lyon?
The bus is the cheapest travel choice for this destination
The cheapest trip from Brussels to Lyon was searched and found on Nov 22, 2025 with a price of $29
The bus is the cheapest travel choice for this destination
