Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Interbus | Rome Tiburtina Bus Station | CheapestFastest | ||||
| Bus | Terminal Interbus | Aeroporto Ciampino Airport (CIA) | No tags |
Last refresh of the prices: Today at 3:06 AM CET.
Compare 2 ways to go from Syracuse to Rome
Among the sustainable travel choices, the Train stands out as a good way to reach Rome. The journey takes about 10 hours 51 minutes and with fares starting at just $58, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Rome?
Stops in Syracuse
- AViale Paolo Orsi, 20, 96100 Siracusa SR, Italy
- B
Siracusa
Piazzale della Stazione Centrale, 21, 96100 Siracusa SR, Italy - C
Siracusa - Terminal Bus (Stazione FS)
Viale Teocrito, 68-74, 96100 Siracusa SR, Italy
Stops in Rome
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Syracuse to Rome by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Syracuse to Rome?
The cheapest bus tickets from Syracuse to Rome start from $40. The average price for this route is around $65. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Rome?
The average bus trip duration from Syracuse to Rome is 19h 25m, covering a distance of 357 miles (575 km). The quickest bus can get you there in 13h 45m and is operated by FlixBus.
Which bus companies service the Syracuse to Rome route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Syracuse to Rome?
The earliest bus departs from Syracuse to Rome at 7:15am. And the latest bus departs at 5:05pm.
What are the CO₂ emissions for the bus trip from Syracuse to Rome?
A bus trip from Syracuse to Rome generates an estimated 14 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse to Rome was searched and found on Mar 14, 2026 with a price of $40To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse to Rome, as early as possible.
You can expect to pay from $40 to $134 for a bus ticket from Syracuse to Rome based on the last 2 days. You can expect to find the cheapest price for the trip at $50 which is on 2026-03-20.
