Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Florence Station | Depew Station | No tags | ||||
| Train | Florence Station | Exchange Street Station | No tags | ||||
| Train | Florence Station | Depew Station | No tags | ||||
| Train | Florence Station | Depew Station | No tags | ||||
| Train | Florence Station | Exchange Street Station | No tags |
Compare 2 ways to go from Florence to Buffalo
Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 1 day, 1 hour and with fares starting at just $119, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5657 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $223
Frequently asked questions about traveling from Florence, SC, US to Buffalo, NY by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Florence to Buffalo?
The cheapest train tickets from Florence to Buffalo start from $223. The average price for this train route is around $293. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Florence to Buffalo?
The average train ride duration from Florence to Buffalo is 22h 10m, covering a distance of 603 miles (973 km). The quickest train can get you there in 21h 49m and is operated by Amtrak.
Which train operators service the Florence to Buffalo route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the train from Florence to Buffalo?
The earliest train departs from Florence to Buffalo at 10:32pm. And the latest train departs at 11:32pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Buffalo, NY was searched and found on Dec 18, 2025 with a price of $222To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Florence, SC, US to Buffalo, NY, as early as possible.
You can expect to pay from $222 to $988 for a train ticket from Florence, SC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $241 which is on 2025-12-20.
