How much is the bus ticket from Florence to Buffalo?

The cheapest bus tickets from Florence to Buffalo start from $119. The average price for this route is around $205. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Florence to Buffalo?

The average bus trip duration from Florence to Buffalo is 1d 1h, covering a distance of 606 miles (976 km). The quickest bus can get you there in 22h 20m and is operated by FlixBus .

Which bus companies service the Florence to Buffalo route?

Several major bus companies operate on this route with 5 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Florence to Buffalo?

The earliest bus departs from Florence to Buffalo at 12:05am. And the latest bus departs at 4:30pm.

What are the CO₂ emissions for the bus trip from Florence to Buffalo?

A bus trip from Florence to Buffalo generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Florence to Buffalo?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11638 reviews.

Which bus company has the best Wi-Fi from Florence to Buffalo?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Florence to Buffalo?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Florence to Buffalo?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Florence to Buffalo from $126 | Refundable Tickets

Previously seen trips

Next departures for Florence to Buffalo on December 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:15pm	Bus station	1d 1h	5:25pm	Niagara Frontier Transportation Authority	No tags
Greyhound + FlixBus	Bus	4:15pm	Bus station	1d 1h	5:30pm	Buffalo (BUF) Airport	No tags
	Bus	11:59pm	Florence, SC	22h 46m	10:45pm	Niagara Frontier Transportation Authority	No tags
	Bus	11:59pm	Florence, SC	22h 26m	10:25pm	Buffalo (BUF) Airport	No tags
	Bus	4:15pm	Bus station	1d 1h	5:25pm	Niagara Frontier Transportation Authority	No tags

Compare 2 ways to go from Florence to Buffalo

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 1 day, 1 hour and with fares starting at just $119, it presents an excellent value for a comfortable ride.

5bus per day

1d 1hAverage Duration

606 milesDistance

24kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$119 - $308	Average Duration1d 1h	CO₂ emissions 24kg CO₂e
Train	Average Price$223 - $493	Average Duration22h 10m	CO₂ emissions 88kg CO₂e

Where are the popular stops in Florence and Buffalo?

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Buffalo

A
Buffalo Airport
Visit page
B
Transportation Center
185 Ellicott St, Buffalo, NY 14203, USA
Visit page
C
Exchange Street Station
75 Exchange St, Buffalo, NY 14203, USA
Visit page

Compare bus companies

FlixBus

3.5/511,663 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,440 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Florence, SC, US to Buffalo, NY by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Buffalo?
The cheapest bus tickets from Florence to Buffalo start from $119. The average price for this route is around $205. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Buffalo?
The average bus trip duration from Florence to Buffalo is 1d 1h, covering a distance of 606 miles (976 km). The quickest bus can get you there in 22h 20m and is operated by FlixBus.
Which bus companies service the Florence to Buffalo route?
Several major bus companies operate on this route with 5 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Florence to Buffalo?
The earliest bus departs from Florence to Buffalo at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Buffalo?
A bus trip from Florence to Buffalo generates an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Florence to Buffalo?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11638 reviews.
Which bus company has the best Wi-Fi from Florence to Buffalo?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Florence to Buffalo?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Florence to Buffalo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/17

No data

12/18

No data

Today

$170

12/20

$150

12/21

$144

12/22

$145

12/23

No data

12/24

No data

The cheapest trip from Florence, SC, US to Buffalo, NY was searched and found on Dec 21, 2025 with a price of $144

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Buffalo, NY, as early as possible.

You can expect to pay from $144 to $170 for a bus ticket from Florence, SC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $144 which is on 2025-12-21.