Next departures for Durham to Chicago on November 24
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Train
Durham Station
Chicago (Union Station), IL
CheapestFastest
Next departures for Durham to Chicago on November 25
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Train
Durham Station
Chicago (Union Station), IL
CheapestFastest
Train
Durham Station
Chicago (Union Station), IL
No tags
Next departures for Durham to Chicago on November 26
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Vehicle type
Departure time
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Train
Durham Station
Chicago (Union Station), IL
CheapestFastest
Train
Durham Station
Chicago (Union Station), IL
No tags
Train
Durham Station
Chicago (Union Station), IL
No tags
Last refresh of the prices: Last Tuesday at 8:55 PM EST.
Compare 2 ways to go from Durham to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 1 hour 55 minutes and with fares starting at just $85, it presents an excellent value for a comfortable ride.
Based on 5594 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $211
Frequently asked questions about traveling from Durham, NC, US to Chicago by train
How much does a train ticket from Durham to Chicago cost?
The average train ticket price from Durham to Chicago is $307. The best way to find train tickets from Durham to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the train trip from Durham to Chicago?
A train trip between Durham and Chicago is around 1d 15h, although the fastest train will take about 1d 15h. This is the time it takes to travel the 620 miles that separates the two cities.
How many daily trains are there between Durham and Chicago?
The number of trains from Durham to Chicago can differ depending on the day of the week. On average, there is 1. Some trains are direct while others have layovers. Simplify your train trip from Durham to Chicago by comparing and selecting the train that fits you travel style and budget on Busbud.
Which train companies travel from Durham to Chicago?
When taking the train from Durham to Chicago, you can travel comfortably and safely with Amtrak.
What are the best sights and things to do in Chicago?
Once in Chicago, you can explore the city. The top sights and things to do are Museum of Contemporary Art, Willis Tower (Sears Tower), Chicago Shakespeare Theater on Navy Pier, Navy Pier, Lincoln Park Zoo.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
$263
11/19
$331
Today
$322
11/21
No data
11/22
No data
11/23
$257
11/24
$1,898
11/25
$322
The cheapest trip from Durham, NC, US to Chicago was searched and found on Nov 23, 2025 with a price of $257
To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Durham, NC, US to Chicago, as early as possible.
You can expect to pay from $257 to $1,898 for a train ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $257 which is on 2025-11-23.
The cheapest trip from Durham, NC, US to Chicago was searched and found on Nov 23, 2025 with a price of $257
