How far is Durham from Chicago?

The distance separating Durham and Chicago is 620 miles (999 km).

What are the departure and arrival stations when taking the bus from Durham to Chicago?

Most of the buses traveling from Durham to Chicago leave from Durham Greyhound Bus Station and arrive at Downtown Greyhound Station. These are the main departure and arrival locations on this route, but you can find others that could fit better into your travel plans.

What are the best sights and things to do in Chicago?

Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Lincoln Park Conservatory, Navy Pier, Brookfield Zoo, Auditorium Building and Theatre and Museum of Science and Industry.

Bus Durham to Chicago from $112 | Refundable Tickets

Next bus departures

Next departures for Durham to Chicago on November 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:05pm	Durham Greyhound Bus Station	1d 1h	11:00pm	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	8:30am	Durham Greyhound Bus Station	1d	7:50am	537-517 W. Jackson Blvd	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	8:30am	Durham Greyhound Bus Station	1d	8:15am	Downtown Greyhound Station	No tags
	Bus	10:05pm	Durham Greyhound Bus Station	1d 1h	10:20pm	Downtown Greyhound Station	No tags
	Bus	9:10am	Durham Greyhound Bus Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Durham to Chicago on November 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	10:05pm	Durham Greyhound Bus Station	1d 1h	11:00pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	2:30am	Durham Greyhound Bus Station	22h 20m	11:50pm	Chicago 95Th & Dan Ryan	Fastest
	Bus	2:30am	Durham Greyhound Bus Station	22h 40m	12:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	8:30am	Durham Greyhound Bus Station	1d	8:15am	Downtown Greyhound Station	No tags
	Bus	4:25pm	Durham Greyhound Bus Station	1d 4h	8:10pm	Downtown Greyhound Station	No tags

Next departures for Durham to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	2:30am	Durham Greyhound Bus Station	22h 20m	11:50pm	Chicago 95Th & Dan Ryan	CheapestFastest
	Bus	2:30am	Durham Greyhound Bus Station	22h 40m	12:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	8:30am	Durham Greyhound Bus Station	1d	8:15am	Downtown Greyhound Station	No tags
	Bus	9:10am	Durham Greyhound Bus Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	2:50pm	Durham Greyhound Bus Station	1d 1h	3:15pm	Downtown Greyhound Station	No tags

Next departures for Durham to Chicago on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	2:30am	Durham Greyhound Bus Station	22h 20m	11:50pm	Chicago 95Th & Dan Ryan	CheapestFastest
	Bus	2:30am	Durham Greyhound Bus Station	22h 40m	12:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	8:30am	Durham Greyhound Bus Station	1d	8:15am	Downtown Greyhound Station	No tags
	Bus	9:10am	Durham Greyhound Bus Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags
FlixBus + Greyhound Lines, Inc.	Bus	2:50pm	Durham Greyhound Bus Station	1d 1h	3:15pm	Downtown Greyhound Station	No tags

Next departures for Durham to Chicago on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	9:15pm	Durham Greyhound Bus Station	1d 2h	11:00pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	2:30am	Durham Greyhound Bus Station	22h 20m	11:50pm	Chicago 95Th & Dan Ryan	Fastest
	Bus	2:30am	Durham Greyhound Bus Station	22h 40m	12:10am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	8:30am	Durham Greyhound Bus Station	1d	8:15am	Downtown Greyhound Station	No tags
	Bus	9:10am	Durham Greyhound Bus Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Yesterday at 10:01 PM EST.

Compare 2 ways to go from Durham to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 1 hour 55 minutes and with fares starting at just $85, it presents an excellent value for a comfortable ride.

13bus per day

1d 1hAverage Duration

619 milesDistance

25kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$85 - $344	Average Duration1d 1h	CO₂ emissions 25kg CO₂e
Train	Average Price$211 - $1,134	Average Duration1d 15h	CO₂ emissions 91kg CO₂e

Where are the popular stops in Durham and Chicago?

Stops in Durham

A
Durham Greyhound Bus Station
515 W Pettigrew St , Durham, NC 27703
Visit page
B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA
C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA
D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

FlixBus

3.5/511,398 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,388 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Durham, NC, US to Chicago by bus

How far is Durham from Chicago?
What are the departure and arrival stations when taking the bus from Durham to Chicago?
What are the best sights and things to do in Chicago?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/20

$145

11/21

$219

Today

$245

11/23

$164

11/24

$133

11/25

$151

11/26

$183

11/27

$128

The cheapest trip from Durham, NC, US to Chicago was searched and found on Nov 27, 2025 with a price of $128

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Chicago, as early as possible.

You can expect to pay from $128 to $340 for a bus ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $128 which is on 2025-11-27.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.