Bus Tickets from Charleston, SC, US to St. Louis

Next departures

Next departures for Charleston to St. Louis on October 16
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
4565 Gaynor Ave, North Charleston
Gateway StationCheapestFastest

Last refresh of the prices: Yesterday at 8:38 PM EDT.

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Bus Charleston, SC, US to St. Louis: Trip Overview

Average Ticket PriceUS$104
Average Bus Trip Duration18h 55m
Number of daily buses1
Earliest bus departure3:15pm
Distance1120 km

Charleston to St. Louis Bus

Busbud helps you find a bus from Charleston to St. Louis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Charleston to St. Louis.

Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Charleston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Charleston, SC, US - St. Louis

  1. What is the distance between Charleston and St. Louis?

    The distance between Charleston and St. Louis is approximately 1133 km (702 miles).

  2. What are the departure and arrival locations for buses traveling from Charleston to St. Louis?

    Buses departing from Charleston Bus Station in Charleston will take you to Gateway Station in St. Louis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-13
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10-14
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Today
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10-16
US$98
10-17
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10-18
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10-19
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busbud logoThe cheapest trip from Charleston, SC, US to St. Louis was searched and found on Oct 16, 2025 with a price of US$98

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charleston, SC, US to St. Louis, as early as possible.

You can expect to pay from US$98 to US$98 for a bus ticket from Charleston, SC, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$98 which is on 2025-10-16.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Charleston and St. Louis!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Charleston to St. Louis.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Charleston to St. Louis.

Tune out to the fine sounds of your best music playlist on your bus trip from Charleston to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Charleston, SC, US by bus?

Bus from St. Louis to Charleston, SC, US

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