Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Charlotte (Uptown) | San Ysidro Bus terminal | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Charlotte Bus Station | San Ysidro Bus terminal | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Charlotte Bus Station | San Ysidro Bus terminal | No tags | ||||
 | Bus | Charlotte Bus Station | San Ysidro Bus terminal | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Charlotte Bus Station | San Ysidro Bus terminal | No tags |
Last refresh of the prices: Last Tuesday at 6:57 AM EST.
Get from Charlotte to San Ysidro
The journey takes about 2 days, 15 hours 25 minutes, and with fares starting at just $364, it presents an excellent value for a comfortable ride.
Where are the popular stops in Charlotte and San Ysidro?
Stops in Charlotte
- A
Tornado & El Expreso Bus Company
4705 N. Tryon S, Charlotte, NC, USA - C
Charlotte Greyhound Bus Station
601 W Trade St , Charlotte, NC 28202 - D
Agencia El Salvador Bus Stop
4335 N Tryon St, Charlotte, NC 28213 - E
4127 Glenwood Dr
4127 Glenwood Dr, Charlotte, NC 28208 (Exxon Gas Station)
Compare bus companies
Based on 87504 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $405
Frequently asked questions about travelling from Charlotte, NC to San Ysidro, CA by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Charlotte to San Ysidro?
The cheapest bus tickets from Charlotte to San Ysidro start from $364. The average price for this route is around $603. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Charlotte to San Ysidro?
The average bus travel time from Charlotte to San Ysidro is 2d 15h, covering a distance of 3331 km. The quickest bus can get you there in 2d 8h and is operated by Greyhound.
Which bus companies service the Charlotte to San Ysidro route?
Several major bus companies operate on this route with 6 buses available per day.
What are the earliest and latest departure times for the bus from Charlotte to San Ysidro?
The earliest bus departs from Charlotte to San Ysidro at 12:55am. And the latest bus departs at 11:40pm.
What are the CO₂ emissions for the bus trip from Charlotte to San Ysidro?
A bus trip from Charlotte to San Ysidro generates an estimated 83 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Charlotte, NC to San Ysidro, CA was searched and found on Jan 19, 2026 with a price of $326To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Charlotte, NC to San Ysidro, CA, as early as possible.
You can expect to pay from $326 to $596 for a bus ticket from Charlotte, NC to San Ysidro, CA based on the last 2 days. You can expect to find the cheapest price for the trip at $326 which is on 2026-01-19.
