Bus Tickets from Chicago to Santa Ana, US

Next departures

Next departures for Chicago to Santa Ana on October 13
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
UC Irvine (Crawford Hall)Cheapest
Greyhound Lines, Inc.
Downtown Greyhound Station
Santa Ana Bus StationFastest
FlixBus + Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
Anaheim Regional Transportation Intermodal CenterNo tags
Greyhound Lines, Inc.
Downtown Greyhound Station
Anaheim Regional Transportation Intermodal CenterNo tags
FlixBus + Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
Anaheim Regional Transportation Intermodal CenterNo tags

Last refresh of the prices: Yesterday at 1:21 AM CDT.

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Bus Chicago to Santa Ana, US: Trip Overview

Average Ticket PriceUS$281
Average Bus Trip Duration2d 5h
Number of daily buses16
Earliest bus departure9:45am
Distance2786 km
Latest bus departure11:50pm

Chicago to Santa Ana Bus

Busbud helps you find a bus from Chicago to Santa Ana. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Chicago to Santa Ana will be provided by the most trusted bus companies.

Discover how much the bus trip from Chicago to Santa Ana will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Chicago - Santa Ana, US

  1. What is the distance between Chicago and Santa Ana?

    The distance between Chicago and Santa Ana is around 2790 km (1730 miles).

  2. What are the departure and arrival locations for buses traveling from Chicago to Santa Ana?

    Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at Santa Ana Greyhound Bus Station, in Santa Ana.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-11
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10-12
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Today
US$347
10-14
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10-15
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10-16
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busbud logoThe cheapest trip from Chicago to Santa Ana, US was searched and found on Oct 13, 2025 with a price of US$347

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Santa Ana, US, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Santa Ana!

Much more than a mere vehicle taking you from Chicago to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Chicago to Santa Ana will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Santa Ana.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Chicago by bus?

Bus from Santa Ana, US to Chicago

Why choose Busbud?

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