Bus Tickets from Columbia, MO to Indianapolis

Find affordable bus tickets from Columbia, MO to Indianapolis with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TomorrowAug 22
from US$69
SatAug 23
SunAug 24
MonAug 25
TueAug 26
WedAug 27
ThuAug 28
FriAug 29

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 22 at
    Departure city: Columbia
    Departure location: Midway Truck Plaza Bus Stop
    Arrival time: August 23 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 22 at
    Departure city: Columbia
    Departure location: Midway Truck Plaza Bus Stop
    Arrival time: August 22 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 22 at
    Departure city: Columbia
    Departure location: Midway Truck Plaza Bus Stop
    Arrival time: August 22 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 22 at
    Departure city: Columbia
    Departure location: Columbia Wabash Station
    Arrival time: August 22 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 22 at
    Departure city: Columbia
    Departure location: Columbia Wabash Station
    Arrival time: August 23 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Columbia, MO to Indianapolis: Trip Overview

Average Ticket PriceUS$83
Average Bus Trip Duration9h 50m
Number of daily buses4
Earliest bus departure8:30am
Distance538 km
Latest bus departure8:35pm

Columbia to Indianapolis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Columbia to Indianapolis.

Bus service from Columbia to Indianapolis will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Columbia to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Columbia, MO - Indianapolis

  1. How far is Columbia from Indianapolis?

    Columbia and Indianapolis are 540 km (335 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Columbia to Indianapolis?

    Buses departing from Midway Truck Plaza Bus Stop in Columbia will take you to Greyhound Amtrak Station in Indianapolis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-19
No data
08-20
No data
Today
No data
08-22
US$61
08-23
No data
08-24
No data
08-25
No data
08-26
No data
busbud logoThe cheapest trip from Columbia, MO to Indianapolis was searched and found on Aug 22, 2025 with a price of US$61

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbia, MO to Indianapolis, as early as possible.

You can expect to pay from US$61 to US$75 for a bus ticket from Columbia, MO to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$61 which is on 2025-08-22.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Columbia to Indianapolis but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Columbia to Indianapolis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Columbia to Indianapolis that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Columbia to Indianapolis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Columbia, MO by bus?

Bus from Indianapolis to Columbia, MO

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Columbia

Buses Leaving from Columbia

Buses Going to Columbia

Popular Buses Connecting Indianapolis

Buses Leaving from Indianapolis

Buses Going to Indianapolis