Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Baytown, 6800 Thompson Rd | Cheapest | ||||
 | Bus | Des Moines | Houston Bus Station | Fastest |
Last refresh of the prices: Yesterday at 10:54 PM CST.
Get from Des Moines to Houston
The journey takes about 1 day, 14 hours 5 minutes, and with fares starting at just $318, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Houston?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Houston
- A
Hillcroft Ave & Southwest Freeway
6590 Southwest Fwy, Houston, TX 77074, USA - B
Downtown Greyhound Station
2121 Main St, Houston, TX 77002 - C
Harrisburg Greyhound Station
7000 Harrisburg Blvd, Houston, TX 77011, USA - D7011 Harrisburg Blvd, Houston, TX 77011, USA
- E
Clay St & Louisiana St
600-698 Clay St, Houston, TX 77002, USA - F
Lockwood Dr & Harvey Wilson Dr
820 Lockwood Dr, Houston, TX 77002, USA
Compare bus companies
Based on 87516 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $318
Frequently asked questions about travelling from Des Moines to Houston, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Des Moines to Houston?
The cheapest bus tickets from Des Moines to Houston start from $318. The average price for this route is around $325. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Des Moines to Houston?
The average bus travel time from Des Moines to Houston is 1d 14h, covering a distance of 1332 km. The quickest bus can get you there in 1d 13h and is operated by Greyhound.
Which bus companies service the Des Moines to Houston route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Des Moines to Houston?
The earliest bus departs from Des Moines to Houston at 9:25am. And the latest bus departs at 9:45am.
What are the CO₂ emissions for the bus trip from Des Moines to Houston?
A bus trip from Des Moines to Houston generates an estimated 33 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Houston, US was searched and found on Jan 20, 2026 with a price of $308To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Houston, US, as early as possible.
You can expect to pay from $308 to $312 for a bus ticket from Des Moines to Houston, US based on the last 2 days. You can expect to find the cheapest price for the trip at $312 which is on 2026-01-23.
