Bus Tickets from Durham, NC, US to Chicago

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ThuSep 4
from US$106
FriSep 5
from US$85
SatSep 6
SunSep 7
MonSep 8
TueSep 9
WedSep 10
ThuSep 11

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: September 5 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: September 5 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: September 6 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: September 6 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: September 6 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 5 at
    Departure city: Durham
    Departure location: Durham Greyhound Bus Station
    Arrival time: September 6 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to go from Durham to Chicago

Bus
Average PriceUS$76 - US$257Average Duration1d 2h
25kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$190 - US$367Average Duration1d 14h
91kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Durham to Chicago

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 2 hours 15 minutes, and with fares starting at just US$76, it presents an excellent value for a comfortable ride.

16bus per day
1d 2hAverage Duration
US$76Cheapest ticket
25kgCO₂ emissions

Bus Durham, NC, US to Chicago: Trip Overview

Average Ticket PriceUS$157
Average Bus Trip Duration1d 2h
Number of daily buses16
Earliest bus departure1:10am
Distance998 km
Latest bus departure10:05pm

Durham to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Durham to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Durham to Chicago.

From cheap bus tickets to more luxurious buses travelling from Durham to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Durham, NC, US - Chicago

  1. How far is Durham from Chicago?

    The distance between Durham and Chicago is around 999 km (620 miles).

  2. What are the departure and arrival locations for buses traveling from Durham to Chicago?

    Buses traveling this route start their trip at Durham Greyhound Bus Station, in Durham, and end it at Downtown Greyhound Station, in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-31
US$109
09-01
No data
Today
US$208
09-03
US$146
09-04
US$110
09-05
US$78
09-06
No data
09-07
No data
busbud logoThe cheapest trip from Durham, NC, US to Chicago was searched and found on Sep 5, 2025 with a price of US$78

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Chicago, as early as possible.

You can expect to pay from US$78 to US$211 for a bus ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$78 which is on 2025-09-05.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Durham to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Durham to Chicago.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Durham to Chicago that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Durham to Chicago while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Durham, NC, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Durham, NC, US by bus?

Bus from Chicago to Durham, NC, US

You can also go to Chicago by train

Train from Durham, NC, US to Chicago

Why choose Busbud?

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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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