Bus Tickets from Florence, SC, US to Gainesville, FL

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Previously seen trips

One passenger / one way

  • Departure time: August 25 at
    Departure city: Florence
    Departure location: Florence Bus Station
    Arrival time: August 25 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 22 at
    Departure city: Florence
    Departure location: Florence, SC
    Arrival time: August 22 at
    Destination city: Gainesville
    Destination location: Rosa Parks Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from Florence to Gainesville

Bus
Average PriceUS$56 - US$76Average Duration8h 30m
14kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$88 - US$96Average Duration14h 53m
51kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Florence to Gainesville

Among the sustainable travel choices, the bus stands out as a good way to reach Gainesville. The journey takes about 8 hours 30 minutes, and with fares starting at just US$56, it presents an excellent value for a comfortable ride.

1bus per day
8h 30mAverage Duration
US$56Cheapest ticket
14kgCO₂ emissions

Bus Florence, SC, US to Gainesville, FL: Trip Overview

Average Ticket PriceUS$56
Average Bus Trip Duration8h 30m
Number of daily buses1
Earliest bus departure5:45am
Distance561 km

Florence to Gainesville Bus

With Busbud, comparing and booking tickets for a bus from Florence to Gainesville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Florence to Gainesville from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Florence to Gainesville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Florence, SC, US - Gainesville, FL

  1. What is the distance between Florence and Gainesville?

    The distance between Florence and Gainesville is around 568 km (352 miles).

  2. What are the departure and arrival locations for buses traveling from Florence to Gainesville?

    Buses traveling this route start their trip at Florence Bus Station, in Florence, and end it at Rosa Parks Station, in Gainesville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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US$68
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busbud logoThe cheapest trip from Florence, SC, US to Gainesville, FL was searched and found on Aug 22, 2025 with a price of US$68

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Gainesville, FL, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Florence to Gainesville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Florence to Gainesville, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Florence to Gainesville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Florence to Gainesville.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

What's the cheapest way to go from Florence, SC, US to Gainesville, FL?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Florence, SC, US by bus?

Bus from Gainesville, FL to Florence, SC, US

You can also go to Gainesville, FL by train

Train from Florence, SC, US to Gainesville, FL

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