Bus Tickets from Indianapolis to Knoxville, TN

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TodayJul 25
TomorrowJul 26
from US$70
SunJul 27
from US$93
MonJul 28
from US$90
TueJul 29
WedJul 30
from US$82
ThuJul 31
FriAug 1

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: July 26 at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: July 26 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: July 26 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: July 26 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 26 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: July 26 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 26 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: July 26 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Saturday at 8:44 AM EDT.

Prices and availability are subject to change.

Accepted payments

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Bus Indianapolis to Knoxville, TN: Trip Overview

Average Ticket PriceUS$91
Average Bus Trip Duration11h 15m
Number of daily buses2
Earliest bus departure4:50am
Distance464 km
Latest bus departure11:30pm

Indianapolis to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Indianapolis to Knoxville will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Indianapolis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Indianapolis - Knoxville, TN

  1. What is the travel distance from Indianapolis to Knoxville?

    Indianapolis and Knoxville are 468 km (290 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Indianapolis to Knoxville?

    Buses departing from Greyhound Amtrak Station in Indianapolis will take you to 100 Kirkwood St in Knoxville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-23
US$123
07-24
No data
Today
No data
07-26
US$74
07-27
US$86
07-28
US$88
07-29
No data
07-30
US$75
busbud logoThe cheapest trip from Indianapolis to Knoxville, TN was searched and found on Jul 26, 2025 with a price of US$74

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Knoxville, TN, as early as possible.

You can expect to pay from US$74 to US$166 for a bus ticket from Indianapolis to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$74 which is on 2025-07-26.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Indianapolis to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Indianapolis to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to Knoxville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Indianapolis to Knoxville.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Will you be returning to Indianapolis by bus?

Bus from Indianapolis to Knoxville, TN

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