Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Downtown Transit Center | Knoxville Bus Station | No tags | ||||
Greyhound + FlixBus | Bus | Downtown Transit Center | Knoxville Bus Station | No tags | ||||
 | Bus | Indianapolis Bus Station | Knoxville Bus Station | No tags | ||||
| Bus | Indianapolis Bus Station | Knoxville Bus Station | No tags | ||||
| Bus | Indianapolis Bus Station | Knoxville Bus Station | No tags |
Get from Indianapolis to Knoxville
This route is served by bus only
The journey takes about 11 hours 15 minutes, and with fares starting at just $100, it presents an excellent value for a comfortable ride.
2bus per day
11h 15mAverage Duration
464 kmDistance
12kgCO₂ emissions
Compare bus companies
US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Where are the popular stops in Indianapolis and Knoxville?
Stops in Indianapolis
Stops in Knoxville
Frequently asked questions about travelling from Indianapolis to Knoxville, TN by bus
What is the travel distance from Indianapolis to Knoxville?
Indianapolis and Knoxville are 468 km (290 miles) apart.
What are the departure and arrival locations for buses traveling from Indianapolis to Knoxville?
Buses departing from Greyhound Amtrak Station in Indianapolis will take you to 100 Kirkwood St in Knoxville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-11
$148
11-12
$152
Today
No data
11-14
$107
11-15
No data
11-16
No data
11-17
No data
11-18
No data
The cheapest trip from Indianapolis to Knoxville, TN was searched and found on Nov 14, 2025 with a price of $107To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Knoxville, TN, as early as possible.
You can expect to pay from $107 to $154 for a bus ticket from Indianapolis to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $107 which is on 2025-11-14.
Top travelled bus routes
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Popular Buses Connecting Indianapolis
Buses Leaving from Indianapolis
- Bus from Indianapolis to Muncie
- Bus Indianapolis - Nashville
- Indianapolis - Chicago
- Bus from Indianapolis to Bloomington
- Bus Indianapolis - Bloomington
- Indianapolis - Temple
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- Bus Indianapolis - St. Louis
- Indianapolis - Milwaukee
- Bus from Indianapolis to Graham
- Bus Indianapolis - Henderson
- Indianapolis - Grand Rapids
- Bus from Indianapolis to Anderson
- Bus Indianapolis - Columbus
- Indianapolis - Denver
Buses Going to Indianapolis
- Bus from South Bend to Indianapolis
- Bus Bloomington - Indianapolis
- Bloomington - Indianapolis
- Bus from Terre Haute to Indianapolis
- Bus Merrillville - Indianapolis
- Greenfield - Indianapolis
- Bus from Chicago to Indianapolis
- Bus New York City - Indianapolis
- St. Louis - Indianapolis
- Bus from Houston to Indianapolis
- Bus Gary - Indianapolis
- Los Angeles - Indianapolis
- Bus from D'Hanis to Indianapolis
- Bus Detroit - Indianapolis
- San Antonio - Indianapolis
Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Marathon
- Knoxville - Lexington
- Bus from Knoxville to Chicago
- Bus Knoxville - Orlando
- Knoxville - Greenville
- Bus from Knoxville to Toledo
- Bus Knoxville - New York City
- Knoxville - Fort Lauderdale
- Bus from Knoxville to Nashville
- Bus Knoxville - Baltimore
- Knoxville - McAllen
- Bus from Knoxville to Opelika
- Bus Knoxville - Evansville
- Knoxville - Northampton
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Detroit - Knoxville
- Bus from Fredericksburg to Knoxville
- Bus Boston - Knoxville
- New York City - Knoxville
- Bus from Port Saint Lucie to Knoxville
- Bus Lynchburg - Knoxville
- Fort Lauderdale - Knoxville
- Bus from Marietta to Knoxville
- Bus San Diego - Knoxville
- Berea - Knoxville
Popular routes in this country
- Bus from Washington to New York City
- Bus Boston - New York City
- New York City - Boston
- Bus from Philadelphia to New York City
- Bus Niagara Falls - New York City
- Buffalo - New York City
- Bus from New York City to Fleischmanns
- Bus Baton Rouge - New Orleans
- Baltimore - New York City
- Bus from Atlanta to Savannah
- Bus Albany - New York City
- New York City - Burlington
- Bus from Las Vegas to Los Angeles
- Bus Los Angeles - San Diego
- Detroit - Chicago