Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Jacksonville Bus Station | 1116 Woodruff Rd | CheapestFastest | ||||
 | Bus | Jacksonville Bus Station | 1116 Woodruff Rd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Jacksonville Bus Station | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Last Wednesday at 11:21 AM EST.
Compare 2 ways to go from Jacksonville to Greenville
Among the sustainable travel choices, the Bus stands out as a good way to reach Greenville. The journey takes about 11 hours 15 minutes, and with fares starting at just $97, it presents an excellent value for a comfortable ride.
Where are the popular stops in Jacksonville and Greenville?
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Compare bus companies
Frequently asked questions about travelling from Jacksonville, FL to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Jacksonville to Greenville?
The cheapest bus tickets from Jacksonville to Greenville start from $97. The average price for this route is around $206. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Jacksonville to Greenville?
The average bus travel time from Jacksonville to Greenville is 11h 15m, covering a distance of 504 km. The quickest bus can get you there in 9h 55m and is operated by Greyhound.
Which bus companies service the Jacksonville to Greenville route?
What are the earliest and latest departure times for the bus from Jacksonville to Greenville?
The earliest bus departs from Jacksonville to Greenville at 8:25am. And the latest bus departs at 9:25pm.
What are the CO₂ emissions for the bus trip from Jacksonville to Greenville?
A bus trip from Jacksonville to Greenville generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Jacksonville to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12050 reviews.
Which bus company has the best Wi-Fi from Jacksonville to Greenville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Jacksonville to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Jacksonville to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to Greenville, SC was searched and found on Jan 16, 2026 with a price of $143To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Greenville, SC, as early as possible.
What's the cheapest way to go from Jacksonville, FL to Greenville, SC?
The Bus is the cheapest travel choice for this destination
