Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Jacksonville Bus Station | Knoxville Bus Station | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Jacksonville Bus Station | Knoxville Bus Station | No tags |
Last refresh of the prices: Today at 8:44 AM EST.
Get from Jacksonville to Knoxville
The journey takes about 13 hours 50 minutes, and with fares starting at just $159, it presents an excellent value for a comfortable ride.
Where are the popular stops in Jacksonville and Knoxville?
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Frequently asked questions about travelling from Jacksonville, FL to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Jacksonville to Knoxville?
The cheapest bus tickets from Jacksonville to Knoxville start from $159. The average price for this route is around $269. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Jacksonville to Knoxville?
The average bus travel time from Jacksonville to Knoxville is 13h 50m, covering a distance of 663 km. The quickest bus can get you there in 13h 50m and is operated by Greyhound.
Which bus companies service the Jacksonville to Knoxville route?
What are the earliest and latest departure times for the bus from Jacksonville to Knoxville?
The earliest bus departs from Jacksonville to Knoxville at 8:00am. And the latest bus departs at 10:05pm.
What are the CO₂ emissions for the bus trip from Jacksonville to Knoxville?
A bus trip from Jacksonville to Knoxville generates an estimated 17 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Jacksonville to Knoxville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Jacksonville to Knoxville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Jacksonville to Knoxville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Jacksonville to Knoxville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to Knoxville, TN was searched and found on Jan 12, 2026 with a price of $221To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Knoxville, TN, as early as possible.
You can expect to pay from $221 to $225 for a bus ticket from Jacksonville, FL to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $225 which is on 2026-01-13.
