Bus Tickets from Jacksonville (FL) to Knoxville (TN)

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TodayJun 14
TomorrowJun 15
MonJun 16
TueJun 17
WedJun 18
from US$115
ThuJun 19
from US$111
FriJun 20
from US$105
SatJun 21

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: June 18 at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: June 18 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 18 at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: June 19 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Wednesday at 3:03 PM EDT.

Prices and availability are subject to change.

Accepted payments

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Bus Jacksonville to Knoxville: Trip Overview

Average Ticket PriceUS$136
Average Bus Trip Duration14h
Number of daily buses2
Earliest bus departure8:05am
Distance663 km
Latest bus departure9:45pm

Jacksonville to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Jacksonville to Knoxville.

We make sure you can find a bus service from Jacksonville to Knoxville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Jacksonville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Jacksonville (FL) - Knoxville (TN)

  1. How long does it take to get to Knoxville from Jacksonville by bus?

    The bus ride from Jacksonville to Knoxville takes 14h, on average. The fastest bus on this trip will get to Knoxville in 13h

  2. What is the distance between Jacksonville and Knoxville?

    The distance between Jacksonville and Knoxville is approximately 662 km (410 miles).

  3. What are the departure and arrival locations for buses traveling from Jacksonville to Knoxville?

    Buses departing from Jacksonville Amtrak Station in Jacksonville will take you to 100 Kirkwood St in Knoxville.

  4. What is the cheapest way to get from Jacksonville to Knoxville?

    Taking the bus is the most budget-friendly option to travel from Jacksonville to Knoxville. The ticket price for this bus starts at US$117, making this your best choice for this trip.

  5. How much is the bus from Jacksonville to Knoxville?

    You can expect to pay around US$136 for the bus ride from Jacksonville to Knoxville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-12
No data
06-13
No data
Today
No data
06-15
US$64
06-16
No data
06-17
No data
06-18
US$108
06-19
No data
busbud logoThe cheapest trip from Jacksonville to Knoxville was searched and found on Jun 15, 2025 with a price of US$64

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville to Knoxville, as early as possible.

You can expect to pay from US$64 to US$108 for a bus ticket from Jacksonville to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at US$64 which is on 2025-06-15.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Jacksonville to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Jacksonville to Knoxville, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Jacksonville to Knoxville will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Jacksonville to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Jacksonville by bus?

Bus from Jacksonville to Knoxville

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