Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Südseite Hauptbahnhof | Terminal Bus Palermo | Cheapest | |||||
 | Südseite Hauptbahnhof | Palermo Centrale | Fastest | |||||
| Südseite Hauptbahnhof | Terminal Bus Palermo | No tags | |||||
Flixtrain + Flixbus | Karlsruhe Hbf | Terminal Bus Palermo | No tags | |||||
| Südseite Hauptbahnhof | Terminal Bus Palermo | No tags |
Last refresh of the prices: Last Tuesday at 5:13 PM CET.
Get from Karlsruhe to Palermo
The journey takes about 1 day, 6 hours 45 minutes, and with fares starting at just $327, it presents an excellent value for a comfortable ride.
Where are the popular stops in Karlsruhe and Palermo?
Stops in Karlsruhe
- AHinterm Hauptbahnhof 6, 76137 Karlsruhe, Germany
- BBahnhofpl. 1A, 76137 Karlsruhe, Germany
- CGoethestraße 17-19, 76135 Karlsruhe, Germany
- D
Karlsruhe
Gartenstraße 58, 76135 Karlsruhe, Germany - E
Karlsruhe/Baden-Baden Airport
Quebec Avenue, 77836 Rheinmünster, Germany
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- EVia Paolo Balsamo, 21, 90123 Palermo, Italy
- F
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy
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Frequently asked questions about travelling from Karlsruhe to Palermo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Karlsruhe to Palermo?
The cheapest bus tickets from Karlsruhe to Palermo start from $327. The average price for this route is around $327. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Karlsruhe to Palermo?
The average bus travel time from Karlsruhe to Palermo is 1d 6h, covering a distance of 1274 km. The quickest bus can get you there in 1d 6h and is operated by OneBus.
Which bus companies service the Karlsruhe to Palermo route?
What are the earliest and latest departure times for the bus from Karlsruhe to Palermo?
The earliest bus departs from Karlsruhe to Palermo at 10:45am. And the latest bus departs at 10:45am.
What are the CO₂ emissions for the bus trip from Karlsruhe to Palermo?
A bus trip from Karlsruhe to Palermo generates an estimated 32 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Karlsruhe to Palermo?
According to Busbud customers, the highest-rated bus company on this route is OneBus, with an average rating of 4.0 out of 5 stars based on 14 reviews.
Which bus company has the best Wi-Fi from Karlsruhe to Palermo?
Based on Busbud reviews, the bus company OneBus has the highest Wi-Fi rating with a score of 5.0.
Which bus company has the best on-time performance from Karlsruhe to Palermo?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Karlsruhe to Palermo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is OneBus, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Karlsruhe to Palermo was searched and found on Jan 5, 2026 with a price of $153To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Palermo, as early as possible.
You can expect to pay from $153 to $297 for a bus ticket from Karlsruhe to Palermo based on the last 0 days. You can expect to find the cheapest price for the trip at $153 which is on 2026-01-05.
Usually OneBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
