Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Niagara Frontier Transportation Authority | No tags | ||||
Greyhound + FlixBus | Bus | Knoxville Bus Station | Niagara Frontier Transportation Authority | No tags | ||||
Greyhound + FlixBus | Bus | Knoxville Bus Station | Buffalo (BUF) Airport | No tags | ||||
| Bus | Knoxville Bus Station | Niagara Frontier Transportation Authority | No tags | ||||
| Bus | Knoxville Bus Station | Niagara Frontier Transportation Authority | No tags |
Get from Knoxville to Buffalo
The journey takes about 18 hours 15 minutes, and with fares starting at just $167, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Buffalo?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Buffalo
- B185 Ellicott St, Buffalo, NY 14203, USA
- C75 Exchange St, Buffalo, NY 14203, USA
Compare bus companies
Based on 87495 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $167
Frequently asked questions about travelling from Knoxville, TN to Buffalo, NY by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Buffalo?
The cheapest bus tickets from Knoxville to Buffalo start from $167. The average price for this route is around $218. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Buffalo?
The average bus travel time from Knoxville to Buffalo is 18h 15m, covering a distance of 878 km. The quickest bus can get you there in 18h 15m and is operated by Greyhound.
Which bus companies service the Knoxville to Buffalo route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Knoxville to Buffalo?
The earliest bus departs from Knoxville to Buffalo at 10:00pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Knoxville to Buffalo?
A bus trip from Knoxville to Buffalo generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Buffalo, NY was searched and found on Jan 14, 2026 with a price of $157To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Buffalo, NY, as early as possible.
You can expect to pay from $157 to $163 for a bus ticket from Knoxville, TN to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $157 which is on 2026-01-14.
