Bus Tickets from Knoxville, TN to Lafayette, IN

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TodayJul 14
TomorrowJul 15
WedJul 16
ThuJul 17
from US$110
FriJul 18
SatJul 19
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MonJul 21

Cheap buses leaving Thursday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: July 17 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: July 18 at
    Destination city: Lafayette
    Destination location: Lafayette Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: July 17 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: July 18 at
    Destination city: Lafayette
    Destination location: Lafayette Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 17 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: July 18 at
    Destination city: Lafayette
    Destination location: Lafayette Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Thursday at 9:50 AM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Knoxville to Lafayette: Trip Overview

Average Ticket PriceUS$96
Average Bus Trip Duration12h 15m
Number of daily buses2
Earliest bus departure6:15pm
Distance558 km
Latest bus departure7:25pm

Knoxville to Lafayette Bus

Busbud helps you find a bus from Knoxville to Lafayette. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Lafayette.

Discover how much the bus trip from Knoxville to Lafayette will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Knoxville, TN - Lafayette, IN

  1. What is the distance between Knoxville and Lafayette?

    It's about 557 km (346 miles) from Knoxville to Lafayette.

  2. What are the departure and arrival locations for buses traveling from Knoxville to Lafayette?

    Buses departing from 100 Kirkwood St in Knoxville will take you to CityBus Center in Lafayette.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-12
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07-13
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Today
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07-15
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07-16
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07-17
US$102
07-18
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07-19
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busbud logoThe cheapest trip from Knoxville to Lafayette was searched and found on Jul 17, 2025 with a price of US$102

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Lafayette, as early as possible.

You can expect to pay from US$102 to US$130 for a bus ticket from Knoxville to Lafayette based on the last 2 days. You can expect to find the cheapest price for the trip at US$102 which is on 2025-07-17.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Knoxville and Lafayette!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Lafayette.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Knoxville to Lafayette will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Knoxville to Lafayette, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Knoxville by bus?

Bus from Knoxville to Lafayette

Why choose Busbud?

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