Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags | ||||
| Bus | Knoxville Bus Station | Gateway Station | No tags |
Get from Knoxville to St. Louis
The journey takes about 15 hours 5 minutes, and with fares starting at just $163, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and St. Louis?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Based on 87500 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $170
Frequently asked questions about travelling from Knoxville, TN to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to St. Louis?
The cheapest bus tickets from Knoxville to St. Louis start from $163. The average price for this route is around $228. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to St. Louis?
The average bus travel time from Knoxville to St. Louis is 15h 5m, covering a distance of 631 km. The quickest bus can get you there in 21h 15m and is operated by Greyhound.
Which bus companies service the Knoxville to St. Louis route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Knoxville to St. Louis?
The earliest bus departs from Knoxville to St. Louis at 6:10pm. And the latest bus departs at 7:40pm.
What are the CO₂ emissions for the bus trip from Knoxville to St. Louis?
A bus trip from Knoxville to St. Louis generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to St. Louis was searched and found on Jan 12, 2026 with a price of $227To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to St. Louis, as early as possible.
