Bus Tickets from Knoxville, TN to St. Louis

Previously seen trips

Next departures for Knoxville to St. Louis on October 12
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Knoxville Bus Station
Gateway StationNo tags
Greyhound
Knoxville Bus Station
Gateway StationNo tags
Greyhound
Knoxville Bus Station
Gateway StationNo tags
Greyhound
Knoxville Bus Station
Gateway StationNo tags
Greyhound
Knoxville Bus Station
Gateway StationNo tags

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Bus Knoxville, TN to St. Louis: Trip Overview

Average Ticket PriceUS$118
Average Bus Trip Duration21h 30m
Number of daily buses2
Earliest bus departure6:10pm
Distance631 km
Latest bus departure7:25pm

Knoxville to St. Louis Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to St. Louis.

From cheap bus tickets to more luxurious buses travelling from Knoxville to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Knoxville, TN - St. Louis

  1. What is the travel distance from Knoxville to St. Louis?

    It's about 630 km (391 miles) from Knoxville to St. Louis.

  2. What are the departure and arrival locations for buses traveling from Knoxville to St. Louis?

    Buses departing from 100 Kirkwood St in Knoxville will take you to Gateway Station in St. Louis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-10
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10-11
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10-13
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10-16
US$83
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busbud logoThe cheapest trip from Knoxville, TN to St. Louis was searched and found on Oct 16, 2025 with a price of US$83

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to St. Louis, as early as possible.

You can expect to pay from US$83 to US$83 for a bus ticket from Knoxville, TN to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$83 which is on 2025-10-16.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Knoxville to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to St. Louis.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to St. Louis that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Knoxville to St. Louis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Knoxville, TN by bus?

Bus from St. Louis to Knoxville, TN

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