Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Panama City Beach Station | Charlotte Bus Station | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Charlotte Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Charlotte Bus Station | No tags | ||||
| Bus | Panama City Beach Station | Charlotte Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Charlotte (Uptown) | No tags |
Last refresh of the prices: Last Wednesday at 12:47 AM CST.
Get from Panama City to Charlotte
The journey takes about 21 hours 35 minutes, and with fares starting at just $163, it presents an excellent value for a comfortable ride.
Where are the popular stops in Panama City and Charlotte?
Stops in Panama City
- A
Panama City Greyhound Bus Station
917 Harrison Ave, Panama City, FL 32401
Stops in Charlotte
- A
Tornado & El Expreso Bus Company
4705 N. Tryon S, Charlotte, NC, USA - C
Charlotte Greyhound Bus Station
601 W Trade St , Charlotte, NC 28202 - D
Agencia El Salvador Bus Stop
4335 N Tryon St, Charlotte, NC 28213 - E
4127 Glenwood Dr
4127 Glenwood Dr, Charlotte, NC 28208 (Exxon Gas Station)
Compare bus companies
Based on 87516 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $163
Frequently asked questions about travelling from Panama City, US to Charlotte, NC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Panama City to Charlotte?
The cheapest bus tickets from Panama City to Charlotte start from $163. The average price for this route is around $213. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Panama City to Charlotte?
The average bus travel time from Panama City to Charlotte is 21h 35m, covering a distance of 726 km. The quickest bus can get you there in 15h 10m and is operated by Greyhound.
Which bus companies service the Panama City to Charlotte route?
Several major bus companies operate on this route with 5 buses available per day.
What are the earliest and latest departure times for the bus from Panama City to Charlotte?
The earliest bus departs from Panama City to Charlotte at 7:30am. And the latest bus departs at 9:40pm.
What are the CO₂ emissions for the bus trip from Panama City to Charlotte?
A bus trip from Panama City to Charlotte generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City, US to Charlotte, NC was searched and found on Jan 29, 2026 with a price of $143To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Charlotte, NC, as early as possible.
You can expect to pay from $143 to $273 for a bus ticket from Panama City, US to Charlotte, NC based on the last 2 days. You can expect to find the cheapest price for the trip at $143 which is on 2026-01-29.
