Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Philadelphia, 199 Spring Garden St | Knoxville Bus Station | CheapestFastest | ||||
 | Bus | 199 Spring Garden St. | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Cherry Hill Mall | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Philadelphia (Logan Square) | Knoxville Bus Station | No tags | ||||
| Bus | Schuylkill & Walnut | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 7:33 AM EST.
Get from Philadelphia to Knoxville
The journey takes about 22 hours, and with fares starting at just $111, it presents an excellent value for a comfortable ride.
Where are the popular stops in Philadelphia and Knoxville?
Stops in Philadelphia
- BOff of Race Street between 5th Street and, N 6th St, Philadelphia, PA 19106, USA
- C
#2842 St.Vincent St
15th St Trolley Station, Philadelphia, PA 19102, USA - D
Bus Station
1001 Filbert St, Philadelphia, PA 19107, USA - E
Island Av & Suffolk Av MBFS
3000 Island Ave, Philadelphia, PA 19153, USA - F
NRG SEPTA Station
3701 Broad St, Philadelphia, PA 19148, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Frequently asked questions about travelling from Philadelphia, PA to Knoxville, TN by bus
What is the travel distance from Philadelphia to Knoxville?
The distance between Philadelphia and Knoxville is around 888 km (551 miles).
What are the departure and arrival locations for buses traveling from Philadelphia to Knoxville?
Buses traveling this route start their trip at Philadelphia Airport, in Philadelphia, and end it at 100 Kirkwood St, in Knoxville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Philadelphia, PA to Knoxville, TN was searched and found on Nov 29, 2025 with a price of $145To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Knoxville, TN, as early as possible.
You can expect to pay from $145 to $391 for a bus ticket from Philadelphia, PA to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $145 which is on 2025-11-29.
