Bus Tickets from Philadelphia, PA to Knoxville, TN

Next departures

Next departures for Philadelphia to Knoxville on October 9
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
199 Spring Garden St.
Knoxville Bus StationCheapest
FlixBus + Greyhound Lines, Inc.
Philadelphia, 199 Spring Garden St
Knoxville Bus StationFastest
FlixBus + Greyhound Lines, Inc.
Philadelphia, 199 Spring Garden St
Knoxville Bus StationNo tags
Greyhound Lines, Inc.
Schuylkill & Walnut
Knoxville Bus StationNo tags
FlixBus + Greyhound Lines, Inc.
Cherry Hill Mall
Knoxville Bus StationNo tags

Last refresh of the prices: Yesterday at 10:29 AM EDT.

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Bus Philadelphia, PA to Knoxville, TN: Trip Overview

Average Ticket PriceUS$84
Average Bus Trip Duration23h
Number of daily buses7
Earliest bus departure1:50am
Distance881 km
Latest bus departure11:15pm

Philadelphia to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Philadelphia to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Philadelphia to Knoxville.

From cheap bus tickets to more luxurious buses travelling from Philadelphia to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Philadelphia, PA - Knoxville, TN

  1. What is the travel distance from Philadelphia to Knoxville?

    The distance between Philadelphia and Knoxville is around 888 km (551 miles).

  2. What are the departure and arrival locations for buses traveling from Philadelphia to Knoxville?

    Buses traveling this route start their trip at Philadelphia Airport, in Philadelphia, and end it at 100 Kirkwood St, in Knoxville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-05
US$82
10-06
US$52
Today
US$43
10-08
US$52
10-09
US$72
10-10
US$81
10-11
No data
10-12
US$79
busbud logoThe cheapest trip from Philadelphia, PA to Knoxville, TN was searched and found on Oct 7, 2025 with a price of US$43

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Knoxville, TN, as early as possible.

You can expect to pay from US$43 to US$84 for a bus ticket from Philadelphia, PA to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$52 which is on 2025-10-08.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Philadelphia to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Philadelphia to Knoxville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Philadelphia to Knoxville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Philadelphia to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Philadelphia, PA by bus?

Bus from Knoxville, TN to Philadelphia, PA

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