Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | City of Portland | Syracuse (Regional Transportation Center) | CheapestFastest |
Last refresh of the prices: Last Thursday at 4:58 PM EST.
Get from Portland to Syracuse
The journey takes about 14 hours 10 minutes, and with fares starting at just $105, it presents an excellent value for a comfortable ride.
Where are the popular stops in Portland and Syracuse?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Compare bus companies
Based on 87499 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $105
Frequently asked questions about travelling from Portland, ME to Syracuse, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Portland to Syracuse?
The cheapest bus tickets from Portland to Syracuse start from $105. The average price for this route is around $201. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Portland to Syracuse?
The average bus travel time from Portland to Syracuse is 14h 10m, covering a distance of 481 km. The quickest bus can get you there in 14h 10m and is operated by Greyhound.
Which bus companies service the Portland to Syracuse route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Portland to Syracuse?
The earliest bus departs from Portland to Syracuse at 1:45pm. And the latest bus departs at 1:45pm.
What are the CO₂ emissions for the bus trip from Portland to Syracuse?
A bus trip from Portland to Syracuse generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Portland, ME to Syracuse, US was searched and found on Jan 14, 2026 with a price of $148To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Portland, ME to Syracuse, US, as early as possible.
You can expect to pay from $148 to $148 for a bus ticket from Portland, ME to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $148 which is on 2026-01-14.
