Bus Tickets from Prague to Brussels

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TodayMay 22
TomorrowMay 23
from US$61
SatMay 24
SunMay 25
MonMay 26
TueMay 27
WedMay 28
ThuMay 29

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: May 23 at
    Departure city: Prague
    Departure location: Florenc
    Arrival time: May 24 at
    Destination city: Brussels
    Destination location: Brussels South (Gare du Midi)
    Operated by: RegioJetRegioJet
    Vehicle: BusDuration:
  • Departure time: May 23 at
    Departure city: Prague
    Departure location: Prague (Central Bus Station Florenc)
    Arrival time: May 24 at
    Destination city: Brussels
    Destination location: Brussels Airport
    Operated by: FlixbusFlixbus
    Vehicle: BusDuration:
  • Departure time: May 23 at
    Departure city: Prague
    Departure location: Prague (Central Bus Station Florenc)
    Arrival time: May 24 at
    Destination city: Brussels
    Destination location: Brussels Airport
    Operated by: FlixbusFlixbus
    Vehicle: BusDuration:
  • Departure time: May 23 at
    Departure city: Prague
    Departure location: Prague (Central Bus Station Florenc)
    Arrival time: May 24 at
    Destination city: Brussels
    Destination location: Brussels Airport
    Operated by: FlixbusFlixbus
    Vehicle: BusDuration:
  • Departure time: May 23 at
    Departure city: Prague
    Departure location: Prague (Central Bus Station Florenc)
    Arrival time: May 24 at
    Destination city: Brussels
    Destination location: Brussels Airport
    Operated by: FlixbusFlixbus
    Vehicle: BusDuration:

Last refresh of the prices: Last Monday at 5:08 PM CEST.

Prices and availability are subject to change.

Accepted payments

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Compare 2 ways to go from Prague to Brussels

Bus
Average PriceUS$40 - US$209Average Duration18h 25m
18kg CO₂e5 out of 5 stars
Cheapest
Train
Average PriceUS$113 - US$373Average Duration13h 21m
17kg CO₂e5 out of 5 stars
FastestMost eco-friendly
busbud logoBusbud recommends taking the bus from Prague to Brussels

Among the sustainable travel choices, the bus stands out as a good way to reach Brussels. The journey takes about 18 hours 25 minutes, and with fares starting at just US$40, it presents an excellent value for a comfortable ride.

15bus per day
18h 25mAverage Duration
US$40Cheapest ticket
18kgCO₂ emissions

Bus Prague to Brussels: Trip Overview

Average Ticket PriceUS$89
Average Bus Trip Duration18h 25m
Number of daily buses15
Earliest bus departure1:00am
Distance720 km
Latest bus departure11:05pm

Prague to Brussels Bus

With Busbud, comparing and booking tickets for a bus from Prague to Brussels is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Prague to Brussels from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Brussels from Prague, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Prague - Brussels

  1. How long does it take to get to Brussels from Prague by bus?

    The bus ride from Prague to Brussels takes 18h 25m, on average. The fastest bus on this trip will get to Brussels in 12h

  2. What is the distance between Prague and Brussels?

    Prague and Brussels are 719 km (446 miles) apart.

  3. What are the departure and arrival locations for buses traveling from Prague to Brussels?

    Buses departing from Florenc in Prague will take you to Brux-Nord in Brussels.

  4. What is the cheapest way to get from Prague to Brussels?

    Taking the bus is the cheapest option to travel from Prague to Brussels. Starting at US$40, this bus is the most cost-effective option for your journey.

  5. How much is the bus from Prague to Brussels?

    The bus from Prague to Brussels will cost you US$89, on average.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-20
US$46
05-21
US$65
Today
US$128
05-23
US$58
05-24
US$119
05-25
US$122
05-26
No data
05-27
US$46
busbud logoThe cheapest trip from Prague to Brussels was searched and found on May 20, 2025 with a price of US$46

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.

You can expect to pay from US$46 to US$162 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at US$46 which is on 2025-05-27.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Prague to Brussels.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Prague to Brussels, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Prague to Brussels.

Make a music playlist for your bus ride from Prague to Brussels, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Prague to Brussels?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Prague by bus?

Bus from Prague to Brussels

You can also go to Brussels by train

Train from Prague to Brussels

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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