Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Prague (Na Knížecí) | Brussels North Train Station | Cheapest | ||||
| Bus | Prague (Na Knížecí) | Brussels North Train Station | Fastest | ||||
| Bus | Prague (Main Railway Station) | Brussels Airport | No tags | ||||
| Bus | Prague (Main Railway Station) | Brussels Airport | No tags | ||||
| Bus | Prague (Main Station - parking) | Brussels Airport | No tags |
Last refresh of the prices: Today at 5:47 PM CET.
Compare 2 ways to go from Prague to Brussels
Among the sustainable travel choices, the bus stands out as a good way to reach Brussels. The journey takes about 18 hours 40 minutes, and with fares starting at just $64, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Brussels?
Stops in Prague
- AAviatická, 161 08, Praha 6, Czechia
- B
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - CTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- DKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- EChlumecká, 198 00 Praha 20, Czech Republic
- F300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
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Frequently asked questions about travelling from Prague to Brussels by bus
What is the distance between Prague and Brussels?
Prague and Brussels are 719 km (446 miles) apart.
What are the departure and arrival locations for buses traveling from Prague to Brussels?
Buses departing from PRG Airport in Prague will take you to Brussels South (Gare du Midi) in Brussels.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Brussels was searched and found on Nov 21, 2025 with a price of $69To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.
You can expect to pay from $69 to $246 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $69 which is on 2025-11-25.
What's the cheapest way to go from Prague to Brussels?
The bus is the cheapest travel choice for this destination
