Next departures for Prague to Brussels on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Prague (Na Knížecí)
Brussels North Train Station
Cheapest
Bus
Prague (Na Knížecí)
Brussels North Train Station
Fastest
Bus
Prague (Main Railway Station)
Brussels Airport
No tags
Bus
Prague (Main Railway Station)
Brussels Airport
No tags
Bus
Prague (Main Station - parking)
Brussels Airport
No tags
Next departures for Prague to Brussels on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels South (Gare du Midi)
CheapestFastest
Next departures for Prague to Brussels on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels-South (Gare du Midi)
CheapestFastest
Next departures for Prague to Brussels on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Florenc
Brussels South (Gare du Midi)
CheapestFastest
Last refresh of the prices: Today at 5:47 PM CET.
Compare 2 ways to go from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just $44, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11150 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $66
Based on 1057 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the departure location and the value for money but often complained with the wifi. RegioJet ticket prices on this trip start at $44
Frequently asked questions about traveling from Prague to Brussels by bus
What is the distance between Prague and Brussels?
The distance between the two cities is 446 miles (719 km).
What are the departure and arrival stations when taking the bus from Prague to Brussels?
If you're headed to Brussels from Prague, chances are that your bus will depart from PRG Airport and arrive at Brussels South (Gare du Midi). These are the primary departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Brussels?
Once in Brussels, you can start exploring the city and discover its surroundings. The top sights and things to do are The Brussels Flower Carpet, a major event on the Grand Place, Visit the Laeken Royal Greenhouses in Brussels, Brussels design market, Le Tour - Brussels Grand Départ and Bright Brussels Festival.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/21
$48
11/22
No data
Today
$84
11/24
$58
11/25
$48
11/26
No data
11/27
$76
11/28
$59
The cheapest trip from Prague to Brussels was searched and found on Nov 21, 2025 with a price of $48
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.
You can expect to pay from $48 to $171 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $48 which is on 2025-11-25.
What's the cheapest way to go from Prague to Brussels?
The bus is the cheapest travel choice for this destination
The cheapest trip from Prague to Brussels was searched and found on Nov 21, 2025 with a price of $48
The bus is the cheapest travel choice for this destination
