How much is the bus ticket from Prague to Brussels?

The cheapest bus tickets from Prague to Brussels start from $45. The average price for this route is around $98. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Prague to Brussels?

The average bus trip duration from Prague to Brussels is 18h 30m, covering a distance of 447 miles (720 km). The quickest bus can get you there in 11h 30m and is operated by FlixBus .

Which bus companies service the Prague to Brussels route?

Several major bus companies operate on this route with 24 buses available per day, including services from FlixBus , BlaBlaCar Bus , RegioJet .

What is the earliest and latest departure time for the bus from Prague to Brussels?

The earliest bus departs from Prague to Brussels at 12:10am. And the latest bus departs at 11:05pm.

What are the CO₂ emissions for the bus trip from Prague to Brussels?

A bus trip from Prague to Brussels generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Prague to Brussels?

According to Busbud customers, the highest-rated bus company on this route is RegioJet , with an average rating of 4.1 out of 5 stars based on 1066 reviews.

Which bus company has the best Wi-Fi from Prague to Brussels?

Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.

Which bus company has the most timely service from Prague to Brussels?

According to Busbud traveller reviews, the most timely bus company on this route is RegioJet , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Prague to Brussels?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet , with a cleanliness rating of 4.4 out of 5 stars.

Bus Prague to Brussels from $42 | Refundable Tickets

Next bus departures

Next departures for Prague to Brussels on January 12
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	10:45pm	PRG Airport	19h 30m	6:15pm	Brussels North Train Station	Cheapest
Bus	9:50am	Prague (Central Bus Station Florenc)	13h 20m	11:10pm	Brussels North Train Station	Fastest
Bus	4:00am	Prague (Main Railway Station)	22h 5m	2:05am	Brussels Airport	No tags
Bus	3:50am	Prague (Main Station - parking)	20h 50m	12:40am	Brussels Airport	No tags
Bus	5:15pm	Prague (Main Station - parking)	1d 1h	6:40pm	Brussels Airport	No tags

Next departures for Prague to Brussels on January 13
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	9:50am	Prague (Central Bus Station Florenc)	13h 20m	11:10pm	Brussels North Train Station	Cheapest
Bus	6:00pm	Florenc	12h	6:00am	Brussels South (Gare du Midi)	Fastest
Bus	10:00pm	Prague (Central Bus Station Florenc)	23h 15m	9:15pm	Brussels Airport	No tags
Bus	4:00am	Prague (Main Railway Station)	22h 5m	2:05am	Brussels Airport	No tags
Bus	6:45pm	Prague (Main Railway Station)	1d 2h	9:15pm	Brussels Airport	No tags

Next departures for Prague to Brussels on January 14
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	1:00pm	Prague (Central Bus Station Florenc)	19h 50m	8:50am	Brussels North Train Station	Cheapest
Bus	6:00pm	Prague (Central Bus Station Florenc)	15h 25m	9:25am	Brussels North Train Station	Fastest
Bus	10:00pm	Prague (Central Bus Station Florenc)	23h 15m	9:15pm	Brussels Airport	No tags
Bus	6:45pm	Prague (Main Railway Station)	1d 2h	9:15pm	Brussels Airport	No tags
Bus	5:30pm	Prague (Main Station - parking)	1d 7h	12:40am	Brussels Airport	No tags

Next departures for Prague to Brussels on January 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	6:00pm	Florenc	12h	6:00am	Brussels South (Gare du Midi)	CheapestFastest

Next departures for Prague to Brussels on January 17
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	7:25am	Prague (Central Bus Station Florenc)	13h 20m	8:45pm	Brussels North Train Station	Cheapest
Bus	9:10am	Prague (Na Knížecí)	11h 35m	8:45pm	Brussels North Train Station	Fastest
Bus	4:00pm	Prague (Central Bus Station Florenc)	17h 25m	9:25am	Brussels Airport	No tags
Bus	6:00pm	Prague (Central Bus Station Florenc)	18h 30m	12:30pm	Brussels Airport	No tags
Bus	8:00pm	Prague (Central Bus Station Florenc)	16h 40m	12:40pm	Brussels Airport	No tags

Last refresh of the prices: Today at 7:08 AM CET.

Compare 2 ways to go from Prague to Brussels

We recommend taking the train

Among the sustainable travel choices, the Train stands out as the good way to reach Brussels. The journey takes about 15 hours 25 minutes and with fares starting at just $62, it presents an excellent value for a comfortable ride.

1train per day

15h 25mAverage Duration

446 milesDistance

17kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$45 - $213	Average Duration18h 30m	CO₂ emissions 18kg CO₂e
Train	Average Price$62 - $329	Average Duration15h 25m	CO₂ emissions 17kg CO₂e

Where are the popular stops in Prague and Brussels?

Stops in Prague

A
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
Visit page Map
B
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
Visit page Map
C
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic
Visit page Map
D
PRG Airport
Aviatická, 161 08, Praha 6, Czechia
Visit page Map
E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic
Map
F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Visit page Map

Stops in Brussels

A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
Visit page Map
B
Brux-Nord
Boulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
Visit page Map
C
Congrès
Pachecolaan 5, 1000 Brussel, Belgium
Visit page Map
D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Map

Compare bus companies

FlixBus

3.5/512,005 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

BlaBlaCar Bus

3.5/511,366 reviews

Staff4.4

Timeliness3.7

Cleanliness4.3

Wifi2.6

RegioJet

4/51,066 reviews

Staff4.5

Timeliness3.9

Cleanliness4.4

Wifi3.8

BE bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Prague to Brussels by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start from $45. The average price for this route is around $98. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Brussels?
The average bus trip duration from Prague to Brussels is 18h 30m, covering a distance of 447 miles (720 km). The quickest bus can get you there in 11h 30m and is operated by FlixBus.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 24 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 12:10am. And the latest bus departs at 11:05pm.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1066 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Prague to Brussels?
According to Busbud traveller reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/09

$70

01/10

$70

Today

$65

01/12

$61

01/13

$45

01/14

$50

01/15

No data

01/16

$48

The cheapest trip from Prague to Brussels was searched and found on Jan 13, 2026 with a price of $45

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels, as early as possible.

You can expect to pay from $45 to $115 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $45 which is on 2026-01-13.