Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Florenc | Brussels South (Gare du Midi) | CheapestFastest |
Last refresh of the prices: Last Friday at 6:33 PM CET.
Compare 2 ways to travel from Prague to Brussels
Among the sustainable travel choices, the bus stands out as a good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just R 754, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Brussels?
Stops in Prague
- ATomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- BKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- CChlumecká, 198 00 Praha 20, Czech Republic
- DAviatická, 161 08, Praha 6, Czechia
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
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Frequently asked questions about travelling from Prague to Brussels by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Prague to Brussels?
The cheapest bus tickets from Prague to Brussels start at R 754. The average price for this route is around R 1 375. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Prague to Brussels?
The average bus journey time from Prague to Brussels is 18h 40m, covering a distance of 710 km. The fastest bus gets you there in 12h and is operated by RegioJet.
Which bus companies service the Prague to Brussels route?
Several major bus companies operate on this route with 19 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Brussels?
The earliest bus departs from Prague to Brussels at 00:10. And the latest bus departs at 23:05.
What are the CO₂ emissions for the bus trip from Prague to Brussels?
A bus trip from Prague to Brussels produces an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Prague to Brussels?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1058 reviews.
Which bus company has the best Wi-Fi from Prague to Brussels?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Prague to Brussels?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Prague to Brussels?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Brussels was searched and found on 17 Dec 2025 with a price of R 766To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Brussels as early as possible.
You can expect to pay from R 766 to R 2 620 for a bus ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at R 766, which is on 2025-12-17.
What's the cheapest way to go from Prague to Brussels?
The bus is the cheapest travel choice for this destination